Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: a panel study

Fabbri, Lorenzo; Garlantézec, Ronan; Audouze, Karine; Bustamante Pineda, Mariona; Carracedo, Ángel; Chatzi, Leda; González, Juan Ramón; Gražulevičienė, Regina; Keun, Hector C.; Lau, Chung-Ho E.; Sabidó, Eduard; Siskos, Alexandros P.; Slama, Rémy; Thomsen, Cathrine; Wright, John; Yuan, Wen Lun; Casas, Maribel; Vrijheid, Martine; Maitre, Léa

Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: a panel study

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dc.contributor.author Fabbri, Lorenzo
dc.contributor.author Garlantézec, Ronan
dc.contributor.author Audouze, Karine
dc.contributor.author Bustamante Pineda, Mariona
dc.contributor.author Carracedo, Ángel
dc.contributor.author Chatzi, Leda
dc.contributor.author González, Juan Ramón
dc.contributor.author Gražulevičienė, Regina
dc.contributor.author Keun, Hector C.
dc.contributor.author Lau, Chung-Ho E.
dc.contributor.author Sabidó, Eduard
dc.contributor.author Siskos, Alexandros P.
dc.contributor.author Slama, Rémy
dc.contributor.author Thomsen, Cathrine
dc.contributor.author Wright, John
dc.contributor.author Yuan, Wen Lun
dc.contributor.author Casas, Maribel
dc.contributor.author Vrijheid, Martine
dc.contributor.author Maitre, Léa
dc.date.accessioned 2023-05-29T08:09:19Z
dc.date.available 2023-05-29T08:09:19Z
dc.date.issued 2023
dc.description.abstract Individuals are exposed to environmental pollutants with endocrine disrupting activity (endocrine disruptors, EDCs) and the early stages of life are particularly susceptible to these exposures. Previous studies have focused on identifying molecular signatures associated with EDCs, but none have used repeated sampling strategy and integrated multiple omics. We aimed to identify multi-omic signatures associated with childhood exposure to non-persistent EDCs. We used data from the HELIX Child Panel Study, which included 156 children aged 6 to 11. Children were followed for one week, in two time periods. Twenty-two non-persistent EDCs (10 phthalate, 7 phenol, and 5 organophosphate pesticide metabolites) were measured in two weekly pools of 15 urine samples each. Multi-omic profiles (methylome, serum and urinary metabolome, proteome) were measured in blood and in a pool urine samples. We developed visit-specific Gaussian Graphical Models based on pairwise partial correlations. The visit-specific networks were then merged to identify reproducible associations. Independent biological evidence was systematically sought to confirm some of these associations and assess their potential health implications. 950 reproducible associations were found among which 23 were direct associations between EDCs and omics. For 9 of them, we were able to find corroborating evidence from previous literature: DEP - serotonin, OXBE - cg27466129, OXBE - dimethylamine, triclosan - leptin, triclosan - serotonin, MBzP - Neu5AC, MEHP - cg20080548, oh-MiNP - kynurenine, oxo-MiNP − 5-oxoproline. We used these associations to explore possible mechanisms between EDCs and health outcomes, and found links to health outcomes for 3 analytes: serotonin and kynurenine in relation to neuro-behavioural development, and leptin in relation to obesity and insulin resistance. This multi-omics network analysis at two time points identified biologically relevant molecular signatures related to non-persistent EDC exposure in childhood, suggesting pathways related to neurological and metabolic outcomes.
dc.description.sponsorship The research leading to these results was supported by the European Community’s Seventh Framework Programme [FP7/2007–2013] under grant agreement no. 308333 [the HELIX project], and by the European Union’s Horizon 2020 research and innovation programme under grant agreements no. 874583 [ATHLETE], and no. 733032 [HBM4EU]. We acknowledge the input of the entire HELIX consortium. We are grateful to all the participating families in the five cohorts (BiB, EDEN, INMA, MoBa, KANC, and RHEA cohorts) that took part in this study. We are equally grateful to all the fieldworkers for their dedication and efficiency in this study. LM is funded by a Juan de la Cierva-Incorporación fellowship (IJC2018-035394-I) awarded by the Spanish Ministerio de Economía, Industria y Competitividad. ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
dc.format.mimetype application/pdf
dc.identifier.citation Fabbri L, Garlantézec R, Audouze K, Bustamante M, Carracedo Á, Chatzi L, et al. Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: a panel study. Environment International. 2023 Mar;173:107856. DOI: 10.1016/j.envint.2023.107856
dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2023.107856
dc.identifier.issn 0160-4120
dc.identifier.uri http://hdl.handle.net/10230/57007
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environment International. 2023 Mar;173:107856
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733032
dc.relation.projectID info:eu-repo/grantAgreement/2PE/CEX2018-000806-S
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Multi-omics
dc.subject.keyword Metabolomics
dc.subject.keyword Endocrine disruptors
dc.subject.keyword Childhood
dc.title Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: a panel study
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Departament de Medicina i Ciències de la Vida)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)