Breast cancer detection risk in screening mammography after a false-positive result

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• dc.contributor.author Castells, Xavier
• dc.contributor.author Román, Marta
• dc.contributor.author Romero, Anabel
• dc.contributor.author Blanch, Jordi
• dc.contributor.author Zubizarreta, Raquel
• dc.contributor.author Ascunce, Nieves
• dc.contributor.author Salas, Dolores
• dc.contributor.author Burón, Andrea
• dc.contributor.author Sala, Maria
• dc.contributor.author Cumulative False Positive Risk Group
• dc.date.accessioned 2025-01-13T08:50:01Z
• dc.date.available 2025-01-13T08:50:01Z
• dc.date.issued 2013
• dc.description.abstract Background: False-positives are a major concern in breast cancer screening. However, false-positives have been little evaluated as a prognostic factor for cancer detection. Our aim was to evaluate the association of false-positive results with the cancer detection risk in subsequent screening participations over a 17-year period. Methods: This is a retrospective cohort study of 762,506 women aged 45-69 years, with at least two screening participations, who underwent 2,594,146 screening mammograms from 1990 to 2006. Multilevel discrete-time hazard models were used to estimate the adjusted odds ratios (OR) of breast cancer detection in subsequent screening participations in women with false-positive results. Results: False-positives involving a fine-needle aspiration cytology or a biopsy had a higher cancer detection risk than those involving additional imaging procedures alone (OR = 2.69; 95%CI: 2.28-3.16 and OR = 1.81; 95%CI: 1.70-1.94, respectively). The risk of cancer detection increased substantially if women with cytology or biopsy had a familial history of breast cancer (OR = 4.64; 95%CI: 3.23-6.66). Other factors associated with an increased cancer detection risk were age 65-69 years (OR = 1.84; 95%CI: 1.67-2.03), non-attendance at the previous screening invitation (OR = 1.26; 95%CI: 1.11-1.43), and having undergone a previous benign biopsy outside the screening program (OR = 1.24; 95%CI: 1.13-1.35). Conclusion: Women with a false-positive test have an increased risk of cancer detection in subsequent screening participations, especially those with a false-positive result involving cytology or biopsy. Understanding the factors behind this association could provide valuable information to increase the effectiveness of breast cancer screening.
• dc.format.mimetype application/pdf
• dc.identifier.citation Castells X, Román M, Romero A, Blanch J, Zubizarreta R, Ascunce N, et al. Breast cancer detection risk in screening mammography after a false-positive result. Cancer Epidemiol. 2013 Feb;37(1):85-90. DOI: 10.1016/j.canep.2012.10.004
• dc.identifier.doi http://dx.doi.org/10.1016/j.canep.2012.10.004
• dc.identifier.issn 1877-7821
• dc.identifier.uri http://hdl.handle.net/10230/69073
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Cancer Epidemiol. 2013 Feb;37(1):85-90
• dc.rights © 2012 Elsevier Ltd. Open access under CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Breast cancer screening
• dc.subject.keyword Cancer detection
• dc.subject.keyword False-positive
• dc.subject.keyword Risk factors
• dc.title Breast cancer detection risk in screening mammography after a false-positive result
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion