Role of CB2 cannabinoid receptor in the development of food addiction in male mice

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  • dc.contributor.author García Blanco, Alejandra
  • dc.contributor.author Ramírez López, Ángela, 1992-
  • dc.contributor.author García-Gutiérrez, María S.
  • dc.contributor.author Manzanares, Jorge
  • dc.contributor.author Martín García, Elena, 1975-
  • dc.contributor.author Maldonado, Rafael, 1961-
  • dc.date.accessioned 2023-05-29T07:51:27Z
  • dc.date.available 2023-05-29T07:51:27Z
  • dc.date.issued 2023
  • dc.description.abstract The endocannabinoid system plays an important role in multiple behavioral responses due to its wide distribution in the central nervous system. The cannabinoid CB1 receptor was associated to the loss of behavioral control over food intake occurring during food addiction. The cannabinoid CB2 receptor (CB2R) is expressed in brain areas canonically associated with addictive-like behavior and was linked to drug-addictive properties. In this study, we evaluated for the first time the specific role of the CB2R in food addiction by using a well-validated operant mouse model of long-term training to obtain highly palatable food. We have compared in this model the behavioral responses of wild-type mice, mutant mice constitutively lacking CB2R, and transgenic mice overexpressing CB2R. The lack of CB2R constitutes a protective factor for the development of food addiction and the impulsive and depressive-like behavior associated. In contrast, the overexpression of CB2R induces a vulnerable phenotype toward food addiction after long-term exposure to highly palatable chocolate pellets. Relevant transcriptomic changes were associated to resilience and vulnerability to food addiction depending on the genotype, which provides a mechanistic explanation for these behavioral changes. Therefore, CB2R may constitute a potential therapeutic target for the loss of eating control and the comorbid emotional effects associated to food addiction.
  • dc.description.sponsorship This work was supported by the Spanish “Ministerio de Ciencia e Innovación (MICIN), Agencia Estatal de Investigación (AEI)” (PID2020-120029GB-I00/MICIN/AEI/10.13039/501100011033, RD21/0009/0019, to RM; the “Generalitat de Catalunya, AGAUR” (2017 SGR-669, to RM; the “ICREA-Acadèmia” (2020) to RM; the “European Commission-DG Research” (PainFact, H2020-SC1–2019-2-RTD-848099, QSPain Relief, H2020-SC1–2019-2-RTD-848068) to RM; the Spanish”la Caixa” Foundation under the project code LCF/PR/HR22/52420017 to R.M., the Spanish “Instituto de Salud Carlos III, RETICS-RTA” (RD16/0017/0020) to RM; the Spanish “Ministerio de Sanidad, Servicios Sociales e Igualdad, Plan Nacional Sobre Drogas” (PNSD- 2021I076, to RM; PNSD- 2019I006, to EMG; Ministerio de Ciencia e Innovación (ERA-NET) PCI2021–122073-2A to EMG; and “Instituto de Salud Carlos III”, Spanish “Ministerio de Ciencia e Innovación” (RD21/0009/0008, “Red de Investigación en Atención Primaria de Adicciones”) to JM.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation García-Blanco A, Ramírez-López Á, Navarrete F, García-Gutiérrez MS, Manzanares J, Martín-García E, Maldonado R. Role of CB2 cannabinoid receptor in the development of food addiction in male mice. Neurobiol Dis. 2023 Apr;179:106034. DOI: 10.1016/j.nbd.2023.106034
  • dc.identifier.doi http://dx.doi.org/10.1016/j.nbd.2023.106034
  • dc.identifier.issn 0969-9961
  • dc.identifier.uri http://hdl.handle.net/10230/57005
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Neurobiology of Disease. 2023 Apr;179:106034
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/848068
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-120029GB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/848099
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PCI2021–122073-2A
  • dc.rights © 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Food addiction
  • dc.subject.keyword CB2R
  • dc.subject.keyword Depressive-like disorder
  • dc.subject.keyword Compulsivity
  • dc.subject.keyword Impulsivity
  • dc.subject.keyword Chocolate
  • dc.title Role of CB2 cannabinoid receptor in the development of food addiction in male mice
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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