Causality in transcription and genome folding: Insights from X inactivation

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• dc.contributor.author Bauer, Moritz, 1987-
• dc.contributor.author Payer, Bernhard
• dc.contributor.author Filion, Guillaume
• dc.date.accessioned 2022-10-25T06:06:45Z
• dc.date.available 2022-10-25T06:06:45Z
• dc.date.issued 2022
• dc.description.abstract The spatial organization of genomes is becoming increasingly understood. In mammals, where it is most investigated, this organization ties in with transcription, so an important research objective is to understand whether gene activity is a cause or a consequence of genome folding in space. In this regard, the phenomena of X-chromosome inactivation and reactivation open a unique window of investigation because of the singularities of the inactive X chromosome. Here we focus on the cause-consequence nexus between genome conformation and transcription and explain how recent results about the structural changes associated with inactivation and reactivation of the X chromosome shed light on this problem.
• dc.description.sponsorship This work was supported by the Spanish Ministry of Science, Innovation and Universities and the Agencia Estatal de Investigacion (AEI, BFU2017-88407-P, EUR2019-103817 to B.P.), the AXA Research Fund (to B.P.) and the Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR, 2017 SGR 346 to B.P.). We would like to thank the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) to the EMBL partnership and to the “Centro de Excelencia Severo Ochoa”. We also acknowledge support of the CERCA Programme of the Generalitat de Catalunya. M.B. is supported by an EMBO postdoctoral fellowship (ALTF 682–2021). G.J.F is supported by NSERC (Discovery Grant RGPIN-2020-06377).
• dc.format.mimetype application/pdf
• dc.identifier.citation Bauer M, Payer B, Filion GJ. Causality in transcription and genome folding: Insights from X inactivation. Bioessays. 2022 Oct;44(10):e2200105. DOI: 10.1002/bies.202200105
• dc.identifier.doi http://dx.doi.org/10.1002/bies.202200105
• dc.identifier.issn 0265-9247
• dc.identifier.uri http://hdl.handle.net/10230/54562
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Bioessays. 2022 Oct;44(10):e2200105
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-88407-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/EUR2019-103817
• dc.rights © 2022 The Authors. BioEssays published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword X-inactivation
• dc.subject.keyword X-reactivation
• dc.subject.keyword Chromatin
• dc.subject.keyword Genome organization
• dc.subject.keyword Transcription
• dc.title Causality in transcription and genome folding: Insights from X inactivation
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion