The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL
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- dc.contributor.author Keller, Theresaca
- dc.contributor.author Hohmann, Cynthiaca
- dc.contributor.author Standl, Marieca
- dc.contributor.author Wijga, Aletca
- dc.contributor.author Gehring, Ulrikeca
- dc.contributor.author Melén, Erikca
- dc.contributor.author Almqvist, Catarinaca
- dc.contributor.author Lau, Susanneca
- dc.contributor.author Eller, Esbenca
- dc.contributor.author Wahn, Ulrichca
- dc.contributor.author Christiansen, E.S.ca
- dc.contributor.author von Berg, Andreaca
- dc.contributor.author Heinrich, Joachimca
- dc.contributor.author Lehmann, Irinaca
- dc.contributor.author Maier, Dieterca
- dc.contributor.author Postma, Dirkje S.ca
- dc.contributor.author Antó i Boqué, Josep Mariaca
- dc.contributor.author Bousquet, Jeanca
- dc.contributor.author Keil, Thomasca
- dc.contributor.author Roll, Stephanieca
- dc.date.accessioned 2018-10-22T15:26:04Z
- dc.date.available 2018-10-22T15:26:04Z
- dc.date.issued 2018
- dc.description.abstract Background - Cross‐sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear whether this inequality changes after puberty. We examined the sex‐specific prevalence of asthma and rhinitis as single and as multimorbid diseases before and after puberty onset in longitudinal cohort data. Methods - In six European population‐based birth cohorts of MeDALL, we assessed the outcomes: current rhinitis, current asthma, current allergic multimorbidity (ie, concurrent asthma and rhinitis), puberty status and allergic sensitization by specific serum antibodies (immunoglobulin E) against aero‐allergens. With generalized estimating equations, we analysed the effects of sex, age, puberty (yes/no) and possible confounders on the prevalence of asthma and rhinitis, and allergic multimorbidity in each cohort separately and performed individual participant data meta‐analysis. Findings - We included data from 19 013 participants from birth to age 14‐20 years. Current rhinitis only affected girls less often than boys before and after puberty onset: adjusted odds ratio for females vs males 0.79 (95%‐confidence interval 0.73‐0.86) and 0.86 (0.79‐0.94), respectively (sex‐puberty interaction P = .089). Similarly, for current asthma only, females were less often affected than boys both before and after puberty onset: 0.71, 0.63‐0.81 and 0.81, 0.64‐1.02, respectively (sex‐puberty interaction P = .327). The prevalence of allergic multimorbidity showed the strongest sex effect before puberty onset (female‐male‐OR 0.55, 0.46‐0.64) and a considerable shift towards a sex‐balanced prevalence after puberty onset (0.89, 0.74‐1.04); sex‐puberty interaction: P < .001. Interpretation - The male predominance in prevalence before puberty and the “sex‐shift” towards females after puberty onset were strongest in multimorbid patients who had asthma and rhinitis concurrently.
- dc.description.sponsorship European Union under the Health Cooperation Work Programme of the 7th Framework Programme. Grant Number: 261357
- dc.format.mimetype application/pdf
- dc.identifier.citation Keller T, Hohmann C, Standl M, Wijga AH, Gehring U, Melén E et al. The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL. Allergy. 2018;73(3):602-14. DOI: 10.1111/all.13312
- dc.identifier.doi http://dx.doi.org/10.1111/all.13312
- dc.identifier.issn 0105-4538
- dc.identifier.uri http://hdl.handle.net/10230/35629
- dc.language.iso eng
- dc.publisher Wileyca
- dc.relation.ispartof Allergy. 2018;73(3):602-14
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
- dc.rights © 2017 The Authors. Allergy Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Asthma
- dc.subject.keyword Birth cohort
- dc.subject.keyword Puberty
- dc.subject.keyword Rhinitis
- dc.title The Sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALLca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion