Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Alonso-Gómez, Ángel
  • dc.contributor.author Tojal Sierra, Lucas
  • dc.contributor.author Fortuny Fraub, Elena
  • dc.contributor.author Goicolea Güemeza, Leire
  • dc.contributor.author Aboitiz Uribarria, Ane
  • dc.contributor.author Portillo, María Puy
  • dc.contributor.author Toledo, Estefania
  • dc.contributor.author Schröder, Helmut, 1958-
  • dc.contributor.author Salas Salvadó, Jordi
  • dc.contributor.author Arós, Fernando
  • dc.date.accessioned 2019-05-22T07:31:17Z
  • dc.date.available 2019-05-22T07:31:17Z
  • dc.date.issued 2018
  • dc.description.abstract BACKGROUND: Left ventricle diastolic dysfunction (LVDD) is a common finding in high risk individuals, its presence being associated with reduced exercise capacity (EC). We assessed the prevalence of LVDD, applying the 2016 guidelines of the American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI), in a population with overweight/obesity and metabolic syndrome and its association with EC. METHODS AND RESULTS: This was a prospective, cross-sectional study of a cohort of 235 patients (mean age of 65 ± 5 years old and 33% female) without heart disease and an ejection fraction >50% who underwent a complete echocardiographic assessment and cardiopulmonary exercise testing. Individuals meeting three or more criteria of the 2016 ASE/EACVI guidelines are considered to have LVDD, while tests are considered indeterminate in those meeting only two. Overall, 178 (76%) of our patients met one echocardiographic cutoff value for LVDD, 91 (39%) met two and 7 (3%) three or more. Patients meeting three cutoffs values showed a significant reduction in maximal oxygen uptake (16 ± 3 vs. 19.6 ± 5 ml/kg/min, p < .05), unlike those with indeterminate tests. In multiple regression analysis, meeting three cutoffs was associated with number of METS (ß = -2.2, p = .018). In exploratory analysis, using two criteria based on cutoffs different from those proposed in the guidelines, we identified groups with different EC. CONCLUSIONS: The application of 2016 ASE/EACVI guidelines limited the prevalence of LVDD to 3%. This group showed a clear reduction of the EC. New echocardiographic cutoff values proposed in this study allow us to establish subgroups with different levels of EC.
  • dc.description.sponsorship This work has been funded by the Carlos III Health Institute (Ministry of Economy, Industry and Competitiveness, Spain) through a FIS project coordinated by Dr. Jordi Salas-Salvadó (PI13/01056), by CIBEROBN (Centre for Biomedical Research Network. Physiopathology of Obesity and Nutrition, Spain) and by the European Research Council, European-Union (Advanced Research Grant 2013–2018; 340918) granted to Dr. Miguel A. González-Martínez.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Alonso-Gómez AM, Tojal Sierra L, Fortuny Frau E, Goicolea Güemez L, Aboitiz Uribarri A, Portillo MP. Et al. Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity. Int J Cardiol Heart Vasc. 2018 Dec 27;22:67-72. DOI: 10.1016/j.ijcha.2018.12.010
  • dc.identifier.doi http://dx.doi.org/10.1016/j.ijcha.2018.12.010
  • dc.identifier.issn 2352-9067
  • dc.identifier.uri http://hdl.handle.net/10230/37254
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof IJC Heart & Vasculature. 2018 Dec 27;22:67-72
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
  • dc.rights © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Diastolic dysfunction
  • dc.subject.keyword Doppler echocardiography
  • dc.subject.keyword Exercise capacity
  • dc.subject.keyword Metabolic syndrome
  • dc.subject.keyword Obesity
  • dc.subject.other Obesitat
  • dc.subject.other Síndrome metabòlica
  • dc.title Diastolic dysfunction and exercise capacity in patients with metabolic syndrome and overweight/obesity
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Hospital del Mar Research Institute)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)