Low zinc levels at admission associates with poor clinical outcomes in SARS-CoV-2 infection

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  • dc.contributor.author Vogel-González, Marina
  • dc.contributor.author Talló Parra, Marc, 1992-
  • dc.contributor.author Herrera-Fernández, Víctor
  • dc.contributor.author Pérez Vilaró, Gemma, 1985-
  • dc.contributor.author Chillón, Miguel
  • dc.contributor.author Nogués Solan, Francesc Xavier
  • dc.contributor.author Gómez-Zorrilla, Silvia
  • dc.contributor.author López Montesinos, Inmaculada
  • dc.contributor.author Arnau-Barrés, Isabel
  • dc.contributor.author Sorli Redó, M. Luisa
  • dc.contributor.author Horcajada Gallego, Juan Pablo
  • dc.contributor.author García-Giralt, Natalia
  • dc.contributor.author Pascual Santos, Julio
  • dc.contributor.author Díez Antón, Juana, 1962-
  • dc.contributor.author Vicente García, Rubén, 1978-
  • dc.contributor.author Güerri Fernández, Roberto
  • dc.date.accessioned 2021-03-10T11:08:54Z
  • dc.date.available 2021-03-10T11:08:54Z
  • dc.date.issued 2021
  • dc.description.abstract Background: Zinc is an essential micronutrient that impacts host-pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with an increased risk for severe severe coronavirus disease 2019 (COVID-19) outcomes. We hypothesize that serum zinc content (SZC) influences COVID-19 disease progression, and thus might represent a useful biomarker. Methods: We ran an observational cohort study with 249 COVID-19 patients admitted in Hospital del Mar. We have studied COVID-19 severity and progression attending to SZC at admission. In parallel, we have studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) replication in the Vero E6 cell line modifying zinc concentrations. Findings: Our study demonstrates a correlation between serum zinc levels and COVID-19 outcome. Serum zinc levels lower than 50 µg/dL at admission correlated with worse clinical presentation, longer time to reach stability, and higher mortality. Our in vitro results indicate that low zinc levels favor viral expansion in SARS-CoV-2 infected cells. Interpretation: Low SZC is a risk factor that determines COVID-19 outcome. We encourage performing randomized clinical trials to study zinc supplementation as potential prophylaxis and treatment with people at risk of zinc deficiency.
  • dc.description.sponsorship This work was supported by the Spanish Ministry of Science and Innovation, through grants PID2019-106755RB-I00/AEI/10.13039/501100011033 to R.V. and PID2019-106959RB-I00/AEI/10.13039/501100011033 to J.D.; an institutional “Maria de Maeztu” Programme for Units of Excellence in R&D (CEX2018-000792-M) to R.V. and J.D.; and by the 2017 SGR 909 grant from the Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement of the Generalitat de Catalunya to J.D. R.G.-F. received support and funding from Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES) (grant number CB16/10/00245), FEDER funds, and the FIS Project from Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (grant number (PI19/00019))
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Vogel-González M, Talló-Parra M, Herrera-Fernández V, Pérez-Vilaró G, Chillón M, Nogués X et al. Low zinc levels at admission associates with poor clinical outcomes in SARS-CoV-2 infection. Nutrients. 2021 Feb 9;13(2):562. DOI: 10.3390/nu13020562
  • dc.identifier.doi http://dx.doi.org/10.3390/nu13020562
  • dc.identifier.issn 2072-6643
  • dc.identifier.uri http://hdl.handle.net/10230/46719
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof Nutrients. 2021 Feb 9;13(2):562
  • dc.rights © 2021 by Marina Vogel-González et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/4.0/)
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.other Zinc en l'organisme
  • dc.subject.other COVID-19 (Malaltia)
  • dc.title Low zinc levels at admission associates with poor clinical outcomes in SARS-CoV-2 infection
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Hospital del Mar Research Institute)