Changes in FIT values below the threshold of positivity and short-term risk of advanced colorectal neoplasia: Results from a population-based cancer screening program

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Buron Pust, Andrea
• dc.contributor.author Román, Marta
• dc.contributor.author Augé, Josep M.
• dc.contributor.author Macià Guilà, Francesc Assís
• dc.contributor.author Grau, Jaume
• dc.contributor.author Sala, Maria
• dc.contributor.author Louro, Javier
• dc.contributor.author Martínez Alonso, Montserrat
• dc.contributor.author Álvarez-Urturi, Cristina
• dc.contributor.author Andreu García, Montserrat
• dc.contributor.author Bessa Caserras, Xavier
• dc.contributor.author Zaffalon-Espinal, Diana Teresa
• dc.contributor.author Castells, Antoni
• dc.contributor.author Pellisé, Maria
• dc.contributor.author Aldea, Marta
• dc.contributor.author Rivero, Liseth
• dc.contributor.author Hernández, Cristina
• dc.contributor.author Torá Rocamora, Isabel, 1979-
• dc.contributor.author Castells, Xavier
• dc.date.accessioned 2025-01-24T13:31:59Z
• dc.date.available 2025-01-24T13:31:59Z
• dc.date.issued 2019
• dc.description.abstract Introduction: Increased values in the fecal immunochemical test (FIT) are correlated with increasingly severe colorectal neoplasia, but little attention has been given to FIT values below the cut-off point (negative FIT, nFIT). We analysed the relationship between the concentrations of two consecutive nFIT and the risk of following screen-detected advanced neoplasia and interval cancer (IC) in a population-based colorectal cancer screening program. Methods: FIT results were categorised into non-detectable nFIT (0-3.8 μg haemoglobin/g feces), low nFIT (3.9-9.9) and high nFIT (10.0-19.9). Multivariable adjusted logistic regression was used to estimate the odds ratios (OR) of advanced neoplasia and IC with the nFIT results in the first two screens. Results: More than 90% of the 42,524 persons had non-detectable nFIT in the first and second screen; 4.5% and 5.8% had a low nFIT, respectively, and 2.2% and 2.9% had a high nFIT. The probability of testing positive and being diagnosed of advanced neoplasia or IC rose with increasing values of nFIT. Compared with those with two non-detectable nFIT results, the highest OR were found among those who had two high nFIT results (OR 21.75; 95% confidence interval: 12.44, 38.04) and those with one low nFIT and one high nFIT (ORs around 20). Conclusions: Participants with nFIT results above the detection limit of the test had an increased risk of advanced neoplasia and IC in subsequent participations. This information could be used in the design of personalised screening strategies.
• dc.format.mimetype application/pdf
• dc.identifier.citation Buron A, Román M, Augé JM, Macià F, Grau J, Sala M, et al. Changes in FIT values below the threshold of positivity and short-term risk of advanced colorectal neoplasia: Results from a population-based cancer screening program. Eur J Cancer. 2019 Jan;107:53-9. DOI: 10.1016/j.ejca.2018.11.004
• dc.identifier.doi http://dx.doi.org/10.1016/j.ejca.2018.11.004
• dc.identifier.issn 0959-8049
• dc.identifier.uri http://hdl.handle.net/10230/69268
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Eur J Cancer. 2019 Jan;107:53-9
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.ejca.2018.11.004
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Cancer
• dc.subject.keyword Cancer screening
• dc.subject.keyword Colon neoplasms
• dc.subject.keyword Fecal occult blood test
• dc.title Changes in FIT values below the threshold of positivity and short-term risk of advanced colorectal neoplasia: Results from a population-based cancer screening program
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion