How to make a synthetic multicellular computer
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- dc.contributor.author Macía, Javierca
- dc.contributor.author Solé Vicente, Ricard, 1962-ca
- dc.date.accessioned 2015-05-22T07:45:21Z
- dc.date.available 2015-05-22T07:45:21Z
- dc.date.issued 2014ca
- dc.description.abstract Biological systems perform computations at multiple scales and they do so in a robust way. Engineering metaphors have often been used in order to provide a rationale for modeling cellular and molecular computing networks and as the basis for their synthetic design. However, a major constraint in this mapping between electronic and wet computational circuits is the wiring problem. Although wires are identical within electronic devices, they must be different when using synthetic biology designs. Moreover, in most cases the designed molecular systems cannot be reused for other functions. A new approximation allows us to simplify the problem by using synthetic cellular consortia where the output of the computation is distributed over multiple engineered cells. By evolving circuits in silico, we can obtain the minimal sets of Boolean units required to solve the given problem at the lowest cost using cellular consortia. Our analysis reveals that the basic set of logic units is typically non-standard. Among the most common units, the so called inverted IMPLIES (N-Implies) appears to be one of the most important elements along with the NOT and AND functions. Although NOR and NAND gates are widely used in electronics, evolved circuits based on combinations of these gates are rare, thus suggesting that the strategy of combining the same basic logic gates might be inappropriate in order to easily implement synthetic computational constructs. The implications for future synthetic designs, the general view of synthetic biology as a standard engineering domain, as well as potencial drawbacks are outlined.en
- dc.description.sponsorship This work has been supported by and EU ERC Advanced Grant, the James S. McDonnell Foundation, the Fundaci’on Botin and the Santa Fe Instituteen
- dc.format.mimetype application/pdfca
- dc.identifier.citation Macia J, Sole R. How to make a synthetic multicellular computer. PLoS ONE. 2014;9(2):e81248. DOI: 10.1371/journal.pone.0081248ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0081248
- dc.identifier.issn 1932-6203ca
- dc.identifier.uri http://hdl.handle.net/10230/23613
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS ONE. 2014;9(2):e81248
- dc.rights © 2014 Macia, Sole. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are crediteden
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Biologia sintèticaca
- dc.subject.other Biologia computacionalca
- dc.title How to make a synthetic multicellular computeren
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca