Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Alfano, Rossella
• dc.contributor.author Plusquin, Michelle
• dc.contributor.author Robinson, Oliver
• dc.contributor.author Brescianini, Sonia
• dc.contributor.author Chatzi, Leda
• dc.contributor.author Keski-Rahkonen, Pekka
• dc.contributor.author Handakas, Evangelos
• dc.contributor.author Maitre, Léa
• dc.contributor.author Nawrot, Tim S.
• dc.contributor.author Robinot, Nivonirina
• dc.contributor.author Roumeliotaki, Theano
• dc.contributor.author Sassi, Franco
• dc.contributor.author Scalbert, Augustin
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Vineis, Paolo
• dc.contributor.author Richiardi, Lorenzo
• dc.contributor.author Zugna, Daniela
• dc.date.accessioned 2022-12-13T06:56:17Z
• dc.date.available 2022-12-13T06:56:17Z
• dc.date.issued 2022
• dc.description.abstract Background: The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overweight in childhood, mediated through cord blood metabolites. Additionally, rapid postnatal growth was considered a potential mediator on childhood overweight, alone and sequentially to each metabolite. Methods: Within four European birth-cohorts (N = 375 mother-child dyads), information on seven prenatal exposures (maternal education, pre-pregnancy BMI, weight gain and tobacco smoke during pregnancy, age at delivery, parity, and child gestational age), selected as obesogenic according to a-priori knowledge, was collected. Cord blood levels of 31 metabolites, associated with rapid postnatal growth and/or childhood overweight in a previous study, were measured via liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry. Rapid growth at 12 months and childhood overweight (including obesity) between four and eight years were defined with reference to WHO growth charts. Single mediation analysis was performed using the imputation approach and multiple mediation analysis using the extended-imputation approach. Results: Single mediation suggested that the effect of maternal education, pregnancy weight gain, parity, and gestational age on rapid postnatal growth but not on childhood overweight was partly mediated by seven metabolites, including cholestenone, decenoylcarnitine(C10:1), phosphatidylcholine(C34:3), progesterone and three unidentified metabolites; and the effect of gestational age on childhood overweight was mainly mediated by rapid postnatal growth. Multiple mediation suggested that the effect of gestational age on childhood overweight was mainly mediated by rapid postnatal growth and that the mediating role of the metabolites was marginal. Conclusion: Our findings provide evidence of the involvement of in utero metabolism in the propensity to rapid postnatal growth and of rapid postnatal growth in the propensity to childhood overweight. We did not find evidence supporting a mediating role of the studied metabolites alone between the studied prenatal exposures and the propensity to childhood overweight.
• dc.description.sponsorship This work is supported by the Bijzonder Onderzoeksfonds Hasselt University through a PhD fellowship [to RA], by the UKRI Future Leaders Fellowship [MR/S03532X/1, to OR] and by the European Commission Horizon 2020 Grant to the ‘STOP Project’ [Grant ref 774548]. The ENVIRONAGE birth cohort is supported by the European Research Council [ERC-2012-StG.310898], and by funds of the Flemish Scientific Research council [FWO, G.0.733.15.N]. The Piccolipiù cohort was initially supported by the Italian National Center for Disease Prevention and Control (CCM grants years 2010 and 2014) and by the Italian Ministry of Health (art 12 and 12 bis D.lgs 502/92). The Rhea study has been funded by various European grants since 2006 and by the Greek Ministry of Health. INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, and the Generalitat de Catalunya-CIRIT. ISGlobal acknowledges support from the Spanish Ministry of Science, Innovation and Universities, “Centro de Excelencia Severo Ochoa 2013-2017”, SEV-2012-0208, and “Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya” (2017SGR595).
• dc.format.mimetype application/pdf
• dc.identifier.citation Alfano R, Plusquin M, Robinson O, Brescianini S, Chatzi L, Keski-Rahkonen P, Handakas E, Maitre L, Nawrot T, Robinot N, Roumeliotaki T, Sassi F, Scalbert A, Vrijheid M, Vineis P, Richiardi L, Zugna D. Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight. Int J Obes (Lond). 2022 Jul;46(7):1384-93. DOI: 10.1038/s41366-022-01108-0
• dc.identifier.doi http://dx.doi.org/10.1038/s41366-022-01108-0
• dc.identifier.issn 0307-0565
• dc.identifier.uri http://hdl.handle.net/10230/55104
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Int J Obes (Lond). 2022 Jul;46(7):1384-93
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/310898
• dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Epidemiology
• dc.subject.keyword Risk factors
• dc.title Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion