Point-of-care hepatitis C testing and treatment strategy for people attending harm reduction and addiction centres for hepatitis C elimination

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• dc.contributor.author Forns, Xavier
• dc.contributor.author Colom, Joan
• dc.contributor.author García-Retortillo, Montserrat
• dc.contributor.author Quer, Joan Carles
• dc.contributor.author Lens, Sabela
• dc.contributor.author Martró, Elisa
• dc.contributor.author Domínguez-Hernández, Raquel
• dc.contributor.author Casado, Miguel Angel
• dc.contributor.author Buti, María
• dc.date.accessioned 2022-09-12T06:51:13Z
• dc.date.available 2022-09-12T06:51:13Z
• dc.date.issued 2022
• dc.description.abstract According to WHO goals, the elimination of Hepatitis C Virus (HCV) by 2030 requires enhancing and simplifying HCV testing. Our aim was to create a model to assess and compare different strategies for HCV testing, linkage to care and treatment among people who access harm reduction centres (HRC) and Addiction Centres in Catalonia. A decision tree model was designed to evaluate two strategies: Hepatitis C Point-of-care (POC) "test and treat", at the community versus standard-of-care (SOC), in which HCV testing was performed at community and therapy at the hospital. Both strategies were assessed separately in HRCs (6,878 users) and Addiction Centres (13,778 users). with a time horizon of 18 months. Healthcare outcomes were HCV testing, linkage to care, treatment outcomes and reinfection rate. HCV testing was performed in 3,178 (46%) of the HRC users. Compared with SOC, POC increased access to treatment by 57% (63% vs. 6%). SVR rates were 64% in POC vs. 23% in SOC. Reinfection rates were 21% with POC compared to 24% with SOC. With POC, losses to follow-up were reduced by 41%. In the Addiction Centres, 12,566 users (91%) were screened using the two strategies. Compared to the SOC, POC increased access to treatment and linkage to care by 19% along with SVR at the same rate. Reinfection rates decreased by 6%. Thus, the implementation of a POC "test and treat" strategy at HRCs and Addiction Centres has shown to be an effective public health strategy to help eliminating HCV in accordance with WHO goal.
• dc.format.mimetype application/pdf
• dc.identifier.citation Forns X, Colom J, García-Retortillo M, Quer JC, Lens S, Martró E, et al. Point-of-care hepatitis C testing and treatment strategy for people attending harm reduction and addiction centres for hepatitis C elimination. J Viral Hepat. 2022 Mar; 29(3): 227-30. DOI: 10.1111/jvh.13634
• dc.identifier.doi http://dx.doi.org/10.1111/jvh.13634
• dc.identifier.issn 1352-0504
• dc.identifier.uri http://hdl.handle.net/10230/54040
• dc.language.iso eng
• dc.publisher Wiley
• dc.rights Copyright © 2021 The Authors. Journal of Viral Hepatitis published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Addiction centres
• dc.subject.keyword Cascade of care
• dc.subject.keyword Drug users
• dc.subject.keyword Harm reduction services
• dc.subject.keyword Hepatitis C virus
• dc.subject.keyword Linkage-to-care
• dc.subject.keyword Test and treat
• dc.title Point-of-care hepatitis C testing and treatment strategy for people attending harm reduction and addiction centres for hepatitis C elimination
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion