Mechanical remodeling of nuclear biomolecular condensates
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- dc.contributor.author Soggia, Giulia
- dc.contributor.author ElMaghloob, Yasmin
- dc.contributor.author Boromangnaeva, Annie-Kermen
- dc.contributor.author Al Jord, Adel
- dc.date.accessioned 2025-01-31T13:20:43Z
- dc.date.embargoEnd info:eu-repo/date/embargoEnd/2025-08-07
- dc.date.issued 2025
- dc.description.abstract Organism health relies on cell proliferation, migration, and differentiation. These universal processes depend on cytoplasmic reorganization driven notably by the cytoskeleton and its force-generating motors. Their activity generates forces that mechanically agitate the cell nucleus and its interior. New evidence from reproductive cell biology revealed that these cytoskeletal forces can be tuned to remodel nuclear membraneless compartments, known as biomolecular condensates, and regulate their RNA processing function for the success of subsequent cell division that is critical for fertility. Both cytoskeletal and nuclear condensate reorganization are common to numerous physiological and pathological contexts, raising the possibility that mechanical remodeling of nuclear condensates may be a much broader mechanism regulating their function. Here, we review this newfound mechanism of condensate remodeling and venture into the contexts of health and disease where it may be relevant, with a focus on reproduction, cancer, and premature aging.
- dc.embargo.liftdate 2025-08-07
- dc.format.mimetype application/pdf
- dc.identifier.citation Soggia G, ElMaghloob Y, Boromangnaeva AK, Al Jord A. Mechanical remodeling of nuclear biomolecular condensates. Physiology (Bethesda). 2025 Jan 1;40(1):0. DOI: 10.1152/physiol.00027.2024
- dc.identifier.doi http://dx.doi.org/10.1152/physiol.00027.2024
- dc.identifier.issn 1548-9213
- dc.identifier.uri http://hdl.handle.net/10230/69411
- dc.language.iso eng
- dc.publisher American Physiological Society
- dc.relation.ispartof Physiology (Bethesda). 2025 Jan 1;40(1):0
- dc.rights © 2025 the American Physiological Society. http://dx.doi.org/10.1152/physiol.00027.2024
- dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
- dc.subject.keyword Aging
- dc.subject.keyword Biomolecular condensates
- dc.subject.keyword Cancer
- dc.subject.keyword Cytoskeleton
- dc.subject.keyword Nucleus
- dc.subject.keyword Oocytes
- dc.title Mechanical remodeling of nuclear biomolecular condensates
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion