Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks

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• dc.contributor.author Krauskopf, Julian
• dc.contributor.author van Veldhoven, Karin
• dc.contributor.author Chadeau-Hyam, Marc
• dc.contributor.author Vermeulen, Roel
• dc.contributor.author Carrasco Turigas, Glòria
• dc.contributor.author Nieuwenhuijsen, Mark J.
• dc.contributor.author Vineis, Paolo
• dc.contributor.author Kok, Theo M. de
• dc.contributor.author Kleinjans, Jos C.
• dc.date.accessioned 2020-01-23T08:35:12Z
• dc.date.available 2020-01-23T08:35:12Z
• dc.date.issued 2019
• dc.description.abstract Traffic-related air pollution (TRAP) is a complex mixture of compounds that contributes to the pathogenesis of many diseases including several types of cancer, pulmonary, cardiovascular and neurodegenerative diseases, and more recently also diabetes mellitus. In search of an early diagnostic biomarker for improved environmental health risk assessment, recent human studies have shown that certain extracellular miRNAs are altered upon exposure to TRAP. Here, we present a global circulating miRNA analysis in a human population exposed to different levels of TRAP. The cross-over study, with sampling taking place during resting and physical activity in two different exposure scenarios, included for each subject personal exposure measurements of PM10,PM2.5, NO, NO2, CO, CO2, BC and UFP. Next-generation sequencing technology was used to identify global circulating miRNA levels across all subjects. We identified 8 miRNAs to be associated with the mixture of TRAP and 27 miRNAs that were associated with the individual pollutants NO, NO2, CO, CO2, BC and UFP. We did not find significant associations between miRNA levels and PM10 or PM2.5. Integrated network analysis revealed that these circulating miRNAs are potentially involved in processes that are implicated in the development of air pollution-induced diseases. Altogether, this study demonstrates that signatures consisting of circulating miRNAs present a potential novel biomarker to be used in health risk assessment.
• dc.description.sponsorship This work has been supported by the European Union within the frame of the Exposomics (226756) project.
• dc.format.mimetype application/pdf
• dc.identifier.citation Krauskopf J, van Veldhoven K, Chadeau-Hyam M, Vermeulen R, Carrasco-Turigas G, Nieuwenhuijsen M et al. Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks. Environ Int. 2019;128:193-200. DOI: 10.1016/j.envint.2019.04.063
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2019.04.063
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/43392
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environment International. 2019;128:193-200
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226756
• dc.rights © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/BY-NC-ND/4.0/
• dc.subject.keyword Air pollution
• dc.subject.keyword Biomarker
• dc.subject.keyword Diesel-exhaust
• dc.subject.keyword Environmental health
• dc.subject.keyword microRNAs
• dc.title Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion