Assessing quality of life in patients with prostate cancer: a systematic and standardized comparison of available instruments

Schmidt, Stefanie, 1979-; Garin Boronat, Olatz, 1979-; Pardo Cladellas, Yolanda; Valderas Martínez, José María; Alonso Caballero, Jordi; Rebollo, Pablo; Rajmil Rajmil, Luis Alberto; García Forero, Carlos; Ferrer Forés, Maria Montserrat; EMPRO Group

Assessing quality of life in patients with prostate cancer: a systematic and standardized comparison of available instruments

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dc.contributor.author Schmidt, Stefanie, 1979-ca
dc.contributor.author Garin Boronat, Olatz, 1979-ca
dc.contributor.author Pardo Cladellas, Yolandaca
dc.contributor.author Valderas Martínez, José Maríaca
dc.contributor.author Alonso Caballero, Jordica
dc.contributor.author Rebollo, Pabloca
dc.contributor.author Rajmil Rajmil, Luis Albertoca
dc.contributor.author García Forero, Carlosca
dc.contributor.author Ferrer Forés, Maria Montserratca
dc.contributor.author EMPRO Groupca
dc.date.accessioned 2015-06-18T07:03:32Z
dc.date.available 2015-06-18T07:03:32Z
dc.date.issued 2014ca
dc.description.abstract Purpose: The objective was to obtain a standardized evaluation of available prostate cancer-specific quality of life instruments used in patients with early-stage disease. Methods: We carried out systematic literature reviews in the PubMed database to identify manuscripts which contained information regarding either the development process or metric properties of prostate cancer-specific quality of life instruments. Each instrument was evaluated by two experts, independently, using the Evaluating Measures of Patient-Reported Outcomes (EMPRO) tool. An overall and seven attribute-specific EMPRO scores were calculated (range 0–100, worst to best): measurement model, reliability, validity, responsiveness, interpretability, burden and alternative forms. Results: Eight instruments and 57 manuscripts (2–15 per instrument) were identified. The Expanded Prostate Cancer Index Composite (EPIC) was the best rated (overall EMPRO score 83.1 points). Good results were also obtained by University of California Los Angeles-Prostate Cancer Index (UCLA-PCI), Patient-Oriented Prostate Utility Scale (PORPUS) and Prostate Cancer Quality of Life Instrument (PC-QoL) with 77.3, 70.5 and 64.8 points, respectively. These four instruments passed with distinction the validity and responsiveness evaluation. Insufficient reliability results were observed for UCLA-PCI and PORPUS. Conclusions: Current evidence supports the choice of EPIC, PORPUS or PC-QoL. Attribute-specific EMPRO results facilitate selecting the adequate instrument for every purpose. For longitudinal studies or clinical trials, where responsiveness is the priority, EPIC or PC-QoL should be considered. We recommend the PORPUS for economic evaluations because it allows cost-utility analysis, and EPIC short versions to minimize administration burden.en
dc.description.sponsorship This study was supported by grants from AGAUR (2012FI_B1 00177; 2009 SGR 1095), Instituto Carlos III FEDER (PS09/02139) and RecerCAIXA (2010ACUP 00158)en
dc.format.mimetype application/pdfca
dc.identifier.citation Schmidt S, Garin O, Pardo Y, Valderas JM, Alonso J, Rebollo P et al. Assessing quality of life in patients with prostate cancer: a systematic and standardized comparison of available instruments. Quality of Life Research. 2014;23(8):2169-81. DOI: 10.1007/s11136-014-0678-8ca
dc.identifier.doi http://dx.doi.org/10.1007/s11136-014-0678-8
dc.identifier.issn 0962-9343ca
dc.identifier.uri http://hdl.handle.net/10230/23854
dc.language.iso engca
dc.publisher SpringerOpenca
dc.relation.ispartof Quality of Life Research. 2014;23(8):2169-81
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Prostatic neoplasmsen
dc.subject.keyword Quality of lifeen
dc.subject.keyword Patient outcomesen
dc.subject.keyword Psychometricsen
dc.subject.keyword Validation studiesen
dc.subject.other Qualitat de vidaca
dc.subject.other Psicometriaca
dc.title Assessing quality of life in patients with prostate cancer: a systematic and standardized comparison of available instrumentsen
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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