Exploring the pathways linking prenatal and early childhood greenness exposure to attention-deficit/hyperactivity disorder symptoms during childhood: An approach based on robust causal inference

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Luque-García, Leire
  • dc.contributor.author García-Baquero, Gonzalo
  • dc.contributor.author Lertxundi, Aitana
  • dc.contributor.author Al-Delaimy, Wael K.
  • dc.contributor.author Julvez, Jordi
  • dc.contributor.author Estarlich, Marisa
  • dc.contributor.author de Castro, Montserrat
  • dc.contributor.author Guxens Junyent, Mònica
  • dc.contributor.author Lozano, Manuel
  • dc.contributor.author Subiza-Pérez, Mikel
  • dc.contributor.author Ibarluzea, Jesús
  • dc.date.accessioned 2024-11-27T07:02:32Z
  • dc.date.available 2024-11-27T07:02:32Z
  • dc.date.issued 2024
  • dc.description.abstract Background: Epidemiological studies suggest that exposure to greenness during childhood may protect children from developing attention-deficit hyperactivity disorder (ADHD). Objective: We analyzed the effect of both prenatal (pregnancy) and early childhood (4-5-year follow-up) residential greenness exposure and green space availability on ADHD symptoms during childhood (up to the age of 12 years) and further explored the potential mediating role of PM2.5 and physical activity in the association. Methods: The study population included participants from the INfancia y Medio Ambiente (INMA) prospective birth cohort (Gipuzkoa, Sabadell, and Valencia). Average Normalized Difference Vegetation Index (NDVI) in buffers of 100-, 300- and 500-m around the residential addresses was used as an indicator of greenness, while green space availability was determined based on the presence of a major green space within 150-m from the residence. Childhood ADHD symptoms were assessed at the 6-8- and 10-12-year follow-ups using Conners Parents Rating Scale-Revised: Short Form. Results: Although no association was found for the prenatal exposure period, increased early childhood NDVI inversely associated with the OR of clinically significant ADHD symptoms during the 6-8-year follow-up at the 100-m (OR 0.03, 95% CI: 0.003 to 0.44), 300-m (OR 0.04, 95% CI: 0.003 to 0.42) and 500-m (OR 0.08, 95% CI: 0.01 to 0.76) buffers, but exclusively in the context of direct effects. Additionally, the 10-12-year follow-up analysis found moderate to weak evidence of potential total and direct effects of NDVI at both 100- and 300-m buffers on inattention scores, as well as for NDVI at the 300-m buffer on ADHD index scores. The analysis did not reveal evidence of mediation through PM2.5 or physical activity. Conclusions: The evidence suggests that early childhood greenness exposure may reduce the risk of developing ADHD symptoms later in childhood, and that this association is not mediated through PM2.5 and physical activity.
  • dc.description.sponsorship INMA-Gipuzkoa cohort was funded by grants from Instituto de Salud Carlos III (FIS-PI06/0867, FIS-PI09/00090, FIS-PI13/02187, FIS-PI18/01142 and FIS-PI18/01237incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), and the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). INMA-Sabadell cohort was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds; PI15/00118 incl. FEDER funds; CP16/00128 incl. FEDER funds; PI16/00118 incl. FEDER funds; PI16/00261 incl. FEDER funds; PI17/01340 incl. FEDER funds; PI18/00547 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds), Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010; EST-2016 RF-21), EU Commission (261357, 308333, 603794 and 634453). We acknowledge support from the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033, and support from the Generalitat de Catalunya through the CERCA Program. INMA-Valencia cohort was funded by Grants from UE (FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1, cod 874583, and cod 101136566), Spain: Instituto de Salud Carlos III (G03/176; FIS-FEDER: PI03/1615, PI04/1509, PI06/1213, PI11/01007, PI11/02591, PI11/02038, PI12/00610, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI17/00663, PI19/1338; P 23/1578), Miguel Servet-FEDER CP11/00178, CP15/00025, MSII16/00051, MS20/0006), Spanish Ministry of Universities (Margarita Salas Grant MS21-133, grant CAS21/00008), Generalitat Valenciana (CIAICO/2021/132, BEST/2020/059, AICO 2020/285, AICO/2021/182 and CIDEGENT/2019/064), Consejo General de Enfermería (PNI22_CGE45), FISABIO (UGP 15-230, UGP-15-244, UGP-15-249), and Alicia Koplowitz Foundation 2017.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Luque-García L, García-Baquero G, Lertxundi A, Al-Delaimy WK, Julvez J, Estarlich M, et al. Exploring the pathways linking prenatal and early childhood greenness exposure to attention-deficit/hyperactivity disorder symptoms during childhood: An approach based on robust causal inference. Int J Hyg Environ Health. 2024 Oct 3;263:114475. DOI: 10.1016/j.ijheh.2024.114475
  • dc.identifier.doi http://dx.doi.org/10.1016/j.ijheh.2024.114475
  • dc.identifier.issn 1438-4639
  • dc.identifier.uri http://hdl.handle.net/10230/68833
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Int J Hyg Environ Health. 2024 Oct 3;263:114475
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
  • dc.rights © 2024 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword ADHD
  • dc.subject.keyword Air pollution
  • dc.subject.keyword Children
  • dc.subject.keyword Green space
  • dc.subject.keyword Physical activity
  • dc.subject.keyword Urban environment
  • dc.title Exploring the pathways linking prenatal and early childhood greenness exposure to attention-deficit/hyperactivity disorder symptoms during childhood: An approach based on robust causal inference
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)