ALCAM shedding at the invasive front of the tumor is a marker of myometrial infiltration and promotes invasion in endometrioid endometrial cancer

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• dc.contributor.author Devis, Laura
• dc.contributor.author Martínez-García, Elena
• dc.contributor.author Moiola, Cristian P.
• dc.contributor.author Quiles, Maria Teresa
• dc.contributor.author Arbós, Maria Antonia
• dc.contributor.author Stirbat, Tomita Vasilica
• dc.contributor.author Brochard-Wyart, Françoise
• dc.contributor.author García, Ángel
• dc.contributor.author Alonso-Alconada, Lorena
• dc.contributor.author Abal, Miguel
• dc.contributor.author Díaz-Feijoo, Berta
• dc.contributor.author Thomas, William
• dc.contributor.author Dufour, Sylvie
• dc.contributor.author Mancebo Moreno, Gemma
• dc.contributor.author Alameda Quitllet, Francisco
• dc.contributor.author Reventós, Jaume
• dc.contributor.author Gil-Moreno, Antonio
• dc.contributor.author Colas, Eva
• dc.date.accessioned 2019-06-28T07:36:05Z
• dc.date.available 2019-06-28T07:36:05Z
• dc.date.issued 2018
• dc.description.abstract Endometrial cancer (EC) is the sixth deadliest cancer in women. The depth of myometrial invasion is one of the most important prognostic factors, being directly associated with tumor recurrence and mortality. In this study, ALCAM, a previously described marker of EC recurrence, was studied by immunohistochemistry at the superficial and the invasive tumor areas from 116 EC patients with different degree of myometrial invasion and related to a set of relevant epithelial and mesenchymal markers. ALCAM expression presented a heterogeneous functionality depending on its localization, it correlated with epithelial markers (E-cadherin/β-catenin) at the superficial area, and with mesenchymal markers at the invasive front (COX-2, SNAIL, ETV5, and MMP-9). At the invasive front, ALCAM-negativity was an independent marker of myometrial invasion. This negativity, together with an increase of soluble ALCAM in uterine aspirates from patients with an invasive EC, and its positive correlation with MMP-9 levels, suggested that ALCAM shedding by MMP-9 occurs at the invasive front. In vivo and in vitro models of invasive EC were generated by ETV5-overexpression. In those, we demonstrated that ALCAM shedding was related to a more invasive pattern and that full-ALCAM recovery reverted most of the ETV5-cells mesenchymal abilities, partially through a p-ERK dependent-manner.
• dc.format.mimetype application/pdf
• dc.identifier.citation Devis L, Martinez-Garcia E, Moiola CP, Quiles MT, Arbos MA, Stirbat TV. Et al. ALCAM shedding at the invasive front of the tumor is a marker of myometrial infiltration and promotes invasion in endometrioid endometrial cancer. Oncotarget. 2018 Mar 30;9(24):16648-16664. DOI: 10.18632/oncotarget.24625
• dc.identifier.doi http://dx.doi.org/10.18632/oncotarget.24625
• dc.identifier.issn 1949-2553
• dc.identifier.uri http://hdl.handle.net/10230/41886
• dc.language.iso eng
• dc.publisher Impact Journal
• dc.rights Copyright : © 2018 Devis et al. This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), https://creativecommons.org/licenses/by/3.0/, which permits unrestricted use and redistribution provided that the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/3.0/
• dc.subject.keyword ALCAM
• dc.subject.keyword ETV5
• dc.subject.keyword MMP-9
• dc.subject.keyword Endometrial cancer
• dc.subject.keyword Myometrial invasion
• dc.title ALCAM shedding at the invasive front of the tumor is a marker of myometrial infiltration and promotes invasion in endometrioid endometrial cancer
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion