High plasma glutamate and a low glutamine-to-glutamate ratio are associated with increased risk of heart failure but not atrial fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Papandreou, Christopher
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Salas Salvadó, Jordi
• dc.date.accessioned 2022-07-04T06:21:59Z
• dc.date.available 2022-07-04T06:21:59Z
• dc.date.issued 2020
• dc.description.abstract Background: Although the association between glutamate and glutamine in relation to cardiometabolic disorders has been evaluated, the role of these metabolites in the development of atrial fibrillation (AF) and heart failure (HF) remains unknown. Objectives: We examined associations of glutamate, glutamine, and the glutamine-to-glutamate ratio with AF and HF incidence in a Mediterranean population at high cardiovascular disease (CVD) risk. Methods: The present study used 2 nested case-control studies within the PREDIMED (Prevención con Dieta Mediterránea) study. During ∼10 y of follow-up, there were 509 AF incident cases matched to 618 controls and 326 HF incident cases matched to 426 controls. Plasma concentrations of glutamate and glutamine were semiquantitatively profiled with LC-tandem MS. ORs were estimated with multivariable conditional logistic regression models. Results: In fully adjusted models, per 1-SD increment, glutamate was associated with a 29% (95% CI: 1.08, 1.54) increased risk of HF and glutamine-to-glutamate ratio with a 20% (95% CI: 0.67, 0.94) decreased risk. Glutamine-to-glutamate ratio was also inversely associated with HF risk (OR per 1-SD increment: 0.80; 95% CI: 0.67, 0.94) when comparing extreme quartiles. Higher glutamate concentrations were associated with a worse cardiometabolic risk profile, whereas a higher glutamine-to-glutamate ratio was associated with a better cardiometabolic risk profile. No associations between the concentrations of these metabolites and AF were observed. Conclusions: Our findings suggest that high plasma glutamate concentrations possibly resulting from alterations in the glutamate-glutamine cycle may contribute to the development of HF in Mediterranean individuals at high CVD risk.This trial was registered at www.isrctn.com as ISRCTN35739639.
• dc.format.mimetype application/pdf
• dc.identifier.citation Papandreou C, Hernández-Alonso P, Bulló M, Ruiz-Canela M, Li J, Guasch-Ferré M et al. High plasma glutamate and a low glutamine-to-glutamate ratio are associated with increased risk of heart failure but not atrial fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study. J Nutr. 2020 Nov 19;150(11):2882-9. DOI: 10.1093/jn/nxaa273
• dc.identifier.doi http://dx.doi.org/10.1093/jn/nxaa273
• dc.identifier.issn 0022-3166
• dc.identifier.uri http://hdl.handle.net/10230/53667
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof J Nutr. 2020 Nov 19;150(11):2882-9
• dc.rights © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of nutrition following peer review. The version of record Papandreou C, Hernández-Alonso P, Bulló M, Ruiz-Canela M, Li J, Guasch-Ferré M et al. High plasma glutamate and a low glutamine-to-glutamate ratio are associated with increased risk of heart failure but not atrial fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study. J Nutr. 2020 Nov 19;150(11):2882-9. DOI: 10.1093/jn/nxaa273 is available online at: https://doi.org/10.1093/jn/nxaa273
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword PREDIMED
• dc.subject.keyword Atrial fibrillation
• dc.subject.keyword Glutamate
• dc.subject.keyword Glutamine
• dc.subject.keyword Heart failure
• dc.title High plasma glutamate and a low glutamine-to-glutamate ratio are associated with increased risk of heart failure but not atrial fibrillation in the Prevención con Dieta Mediterránea (PREDIMED) Study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion