Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis

Schellhas, Laura; Monasso, Giulietta S.; Felix, Janine Frédérique; Jaddoe, Vincent W. V.; Huang, Peiyuan; Fernández-Barrés, Sílvia; Vrijheid, Martine; Pesce, Giancarlo; Annesi-Maesano, Isabella; Page, Christian M.; Brantsaeter, Anne Lise; Bekkhus, Mona; Håberg, Siri E.; London, Stephanie J.; Munafò, Marcus R.; Zuccolo, Luisa; Sharp, Gemma C.

Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis

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dc.contributor.author Schellhas, Laura
dc.contributor.author Monasso, Giulietta S.
dc.contributor.author Felix, Janine Frédérique
dc.contributor.author Jaddoe, Vincent W. V.
dc.contributor.author Huang, Peiyuan
dc.contributor.author Fernández-Barrés, Sílvia
dc.contributor.author Vrijheid, Martine
dc.contributor.author Pesce, Giancarlo
dc.contributor.author Annesi-Maesano, Isabella
dc.contributor.author Page, Christian M.
dc.contributor.author Brantsaeter, Anne Lise
dc.contributor.author Bekkhus, Mona
dc.contributor.author Håberg, Siri E.
dc.contributor.author London, Stephanie J.
dc.contributor.author Munafò, Marcus R.
dc.contributor.author Zuccolo, Luisa
dc.contributor.author Sharp, Gemma C.
dc.date.accessioned 2024-06-19T06:05:32Z
dc.date.available 2024-06-19T06:05:32Z
dc.date.issued 2023
dc.description.abstract Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials & methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12-22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings.
dc.description.sponsorship This research was also conducted as part of the Childhood and Adolescence Psychopathology: Unravelling the Complex Etiology by a Large Interdisciplinary Collaboration in Europe) project, funded by the EU’s Horizon 2020 research and innovation program, Marie Sklodowska Curie Actions – MSCA-ITN-2016 – Innovative Training Networks under grant agreement no. 721567. GC Sharp is financially supported by an MRC New Investigator Research (grant code MR/S009310/1), an MRC project grant (MR/W020297/1) and the European Joint Programming Initiative ‘A Healthy Diet for a Healthy Life’ (JPI HDHL, NutriPROGRAM project, UK MRC MR/S036520/1). BiB: BiB receives core funding from the Wellcome Trust (WT101597MA), the British Heart Foundation (CS/16/4/32482), a joint grant from the UK MRC and UK Economic and Social Science Research Council (MR/N024397/1) and the National Institute for Health Research under its Collaboration for Applied Health Research and Care for Yorkshire and Humber. The research presented in this paper, including obtaining genome-wide and epigenome-wide DNA methylation data is supported by the US NIH (R01 DK10324) and European Research Council (ERC) under the EU’s Seventh Framework Programme (FP7/2007-2013) ERC grant agreement no. 669545. Generation R: The general design of the Generation R Study is made possible by financial support from the Erasmus MC, Erasmus University Rotterdam, The Netherlands Organization for Health Research and Development and the Ministry of Health, Welfare and Sport. The EWAS data were funded by a grant to VW Jaddoe from The Netherlands Genomics Initiative/Netherlands Organisation for Scientific Research Netherlands Consortium for Healthy Aging (project no. 050-060-810), by funds from the Genetic Laboratory of the Department of Internal Medicine, Erasmus MC and by a grant from the National Institute of Child and Human Development (R01HD068437). VW Jaddoe received a Consolidator Grant from the European Research Council (ERC-2014-CoG-648916). This project received funding from the EU’s Horizon 2020 research and innovation program (733206, LifeCycle; 874739, LongITools; 874583, ATHLETE; 824989, EUCAN-Connect) and from the European JPI HDHL (NutriPROGRAM project, ZonMw The Netherlands no. 529051022 and PREcisE project ZonMw The Netherlands no. 529051023). MoBa: The Norwegian Mother, Father and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research. MoBa 1 and 2 were supported by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (Z01-ES-49019), NIH/National Institute of Environmental Health Sciences contract no. N01-ES-75558, the Norwegian Research Council/BIOBANK (grant no. 221097). This work was partly supported by the Research Council of Norway through its Centres of Excellence funding scheme, project no. 262700. Where authors are identified as personnel of the International Agency for Research on Cancer/WHO, the authors alone are responsible for the views expressed in this article and they do not necessarily represent the decisions, policy or views of the International Agency for Research on Cancer/WHO. INMA: This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, PI041436, PI081151 incl. FEDER funds), Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430), EU Commission (261357-MeDALL: Mechanisms of the Development of Allergy), European Research Council (268479-BREATHE: Brain Development and Air Pollution Ultrafine Particles in School Children) and the European JPI HDHL (and Instituto de Salud Carlos III) under the grant agreement no. AC18/00006 (NutriPROGRAM project). We acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the Centro de Excelencia Severo Ochoa 2019–2023 Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the Research Centres of Catalonia Program. EDEN: Foundation for Medical Research (FRM), National Agency for Research (ANR), National Institute for Research in Public health (IRESP: TGIR cohorte santé 2008 program), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A) and Human Nutrition National Research Programs, Paris-Sud University, Nestlé, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), the EU FP7 programs (FP7/2007-2013, HELIX, ESCAPE, ENRIECO, Medall projects), Diabetes National Research Program (in collaboration with the French Association of Diabetic Patients [AFD]), French Agency for Environmental Health Safety (now ANSES), Mutuelle Générale de l’Education Nationale complementary health insurance, French National Agency for Food Security, French Speaking Association for the Study of Diabetes and Metabolism (ALFEDIAM), Sao Paulo Research Foundation (FAPESP) grant no. 2012/51290-6, and EU-funded MeDALL project. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
dc.format.mimetype application/pdf
dc.identifier.citation Schellhas L, Monasso GS, Felix JF, Jaddoe VW, Huang P, Fernández-Barrés S, et al. Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis. Epigenomics. 2023 Nov;15(22):1179-93. DOI: 10.2217/epi-2023-0263
dc.identifier.doi http://dx.doi.org/10.2217/epi-2023-0263
dc.identifier.issn 1750-1911
dc.identifier.uri http://hdl.handle.net/10230/60518
dc.language.iso eng
dc.publisher Taylor & Francis
dc.relation.ispartof Epigenomics. 2023 Nov;15(22):1179-93
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/721567
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/648916
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874739
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/824989
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/268479
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-00080
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword DNA methylation
dc.subject.keyword PACE consortium
dc.subject.keyword Caffeine
dc.subject.keyword Epigenetics
dc.subject.keyword Offspring health
dc.subject.keyword Pregnancy
dc.title Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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