Metabolomics predicts the pharmacological profile of new psychoactive substances
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- dc.contributor.author Olesti Muñoz, Eulàlia, 1991-
- dc.contributor.author De Toma, Ilario
- dc.contributor.author Ramaekers, Johannes G.
- dc.contributor.author Brunt, Tibor M.
- dc.contributor.author Carbó Banús, Marcel·lí
- dc.contributor.author Fernández-Avilés, Cristina
- dc.contributor.author Robledo, Patricia, 1958-
- dc.contributor.author Farré Albaladejo, Magí
- dc.contributor.author Dierssen, Mara
- dc.contributor.author Pozo Mendoza, Óscar J., 1975-
- dc.contributor.author Torre Fornell, Rafael de la
- dc.date.accessioned 2019-07-23T08:27:09Z
- dc.date.available 2019-07-23T08:27:09Z
- dc.date.issued 2019
- dc.description.abstract BACKGROUND: The unprecedented proliferation of new psychoactive substances (NPS) threatens public health and challenges drug policy. Information on NPS pharmacology and toxicity is, in most cases, unavailable or very limited and, given the large number of new compounds released on the market each year, their timely evaluation by current standards is certainly challenging. AIMS: We present here a metabolomics-targeted approach to predict the pharmacological profile of NPS. METHODS: We have created a machine learning algorithm employing the quantification of monoamine neurotransmitters and steroid hormones in rats to predict the similarity of new drugs to classical ones of abuse (MDMA (3,4-methyl enedioxy methamphetamine), methamphetamine, cocaine, heroin and Δ9-tetrahydrocannabinol). RESULTS: We have characterized each classical drug of abuse and two examples of NPS (mephedrone and JWH-018) following alterations observed in the targeted metabolome profile (monoamine neurotransmitters and steroid hormones) in different brain areas, plasma and urine at 1 h and 4 h post drug/vehicle administration. As proof of concept, our model successfully predicted the pharmacological profile of a synthetic cannabinoid (JWH-018) as a cannabinoid-like drug and synthetic cathinone (mephedrone) as a MDMA-like psychostimulant. CONCLUSION: Our approach allows a fast NPS pharmacological classification which will benefit both drug risk evaluation policies and public health.
- dc.format.mimetype application/pdf
- dc.identifier.citation Olesti E, De Toma I, Ramaekers JG, Brunt TM, Carbó ML, Fernández-Avilés C et al. Metabolomics predicts the pharmacological profile of new psychoactive substances. J Psychopharmacol. 2019;33(3):347-54. DOI: 10.1177/0269881118812103
- dc.identifier.doi http://dx.doi.org/10.1177/0269881118812103
- dc.identifier.issn 0269-8811
- dc.identifier.uri http://hdl.handle.net/10230/42139
- dc.language.iso eng
- dc.publisher SAGE Publications
- dc.relation.ispartof Journal of Psychopharmacology. 2019;33(3):347-54
- dc.rights Olesti E, De Toma I, Ramaekers JG, Brunt TM, Carbó ML, Fernández-Avilés C, Robledo P, Farré M, Dierssen M, Pozo ÓJ, de la Torre R. Metabolomics predicts the pharmacological profile of new psychoactive substances. J Psychopharmacol. 2019; 33(3):347-354. Copyright 2019 . DOI: 10.1177/0269881118812103.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Targeted metabolomics
- dc.subject.keyword New psychoactive substances
- dc.subject.keyword Predicted pharmacology
- dc.title Metabolomics predicts the pharmacological profile of new psychoactive substances
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion