Soy isoflavone extract does not increase the intoxicating effects of acute alcohol ingestion in human volunteers
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Martínez Riera, Roser
- dc.contributor.author Pérez Mañá, Clara
- dc.contributor.author Papaseit Fontanet, Esther
- dc.contributor.author Fonseca Casals, Francina, 1972-
- dc.contributor.author Torre Fornell, Rafael de la
- dc.contributor.author Pizarro Lozano, Mª Nieves
- dc.contributor.author Torrens, Marta
- dc.contributor.author Farré Albaladejo, Magí
- dc.date.accessioned 2019-03-27T08:52:19Z
- dc.date.available 2019-03-27T08:52:19Z
- dc.date.issued 2019
- dc.description.abstract Soy beans contain isoflavones, including daidzein and genistein, with biological activities related to therapeutic effects in reducing osteoporosis, decreasing adverse menopausal manifestations, providing protection from cardiovascular diseases, and reducing hormone-dependent cancers and age-related cognitive-decline. Daidzein has been described as inhibiting the aldehyde-dehydrogenase-2 enzyme (ALDH2), and reducing alcohol use in clinical pilot studies. Our aim was to evaluate the possible interactions between a soy extract product and alcohol in a crossover, single blind, randomized study. Ten healthy male volunteers participated in two experimental sessions: one with a single dose of alcohol (0.5 g/kg, Vodka Absolut, Sweden), and the other with four capsules of a soy extract product (Super-Absorbable Soy Isoflavones, Life-Extension, United States) and, 2 h later, the same dose of alcohol. Results showed no differences in vital signs except a slightly higher significative reduction in diastolic blood pressure at 2, 3, 4, and 8 h after administration with alcohol alone in comparison with soy extract+alcohol. Ethanol-induced subjective and adverse effects were similar for both conditions with the exception of headache (higher at 8 h after alcohol alone). Our results demonstrate that a single dose of a soy isoflavone extract did not influence alcohol pharmacokinetics and pharmacological effects and did not induce any disulfiram-reaction symptoms. Soy extract and alcohol did not interact and can be administered safely.
- dc.format.mimetype application/pdf
- dc.identifier.citation Martínez-Riera R, Pérez-Mañá C, Papaseit E, Fonseca F, de la Torre R, Pizarro N et al. Soy isoflavone extract does not increase the intoxicating effects of acute alcohol ingestion in human volunteers. Front Pharmacol. 2019;10:131. DOI: 10.3389/fphar.2019.00131
- dc.identifier.doi http://dx.doi.org/10.3389/fphar.2019.00131
- dc.identifier.issn 1663-9812
- dc.identifier.uri http://hdl.handle.net/10230/36981
- dc.language.iso eng
- dc.publisher Frontiers
- dc.relation.ispartof Frontiers in Pharmacology. 2019;10:131
- dc.rights © 2019 Martínez-Riera, Pérez-Mañá, Papaseit, Fonseca, de la Torre, Pizarro, Torrens and Farré. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Soy extracts
- dc.subject.keyword Isoflavones
- dc.subject.keyword Daidzein
- dc.subject.keyword Genistein
- dc.subject.keyword Aldehyde-dehydrogenase-2 enzyme
- dc.subject.keyword Alcohol
- dc.subject.keyword Clinical trial
- dc.title Soy isoflavone extract does not increase the intoxicating effects of acute alcohol ingestion in human volunteers
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion