Shift work and colorectal cancer risk in the MCC-Spain case-control study
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- dc.contributor.author Papantoniou, Kyriaki, 1983-
- dc.contributor.author Espinosa Díaz, Ana
- dc.contributor.author Castaño Vinyals, Gemma
- dc.contributor.author Turner, Michelle C.
- dc.contributor.author Kogevinas, Manolis
- dc.date.accessioned 2024-05-28T10:09:15Z
- dc.date.available 2024-05-28T10:09:15Z
- dc.date.issued 2017
- dc.description.abstract Objectives Shift work that involves circadian disruption has been associated with a higher cancer risk. Most epidemiological studies to date have focused on breast cancer risk and evidence for other common tumors is limited. We evaluated the risk for colorectal cancer (CRC) in relation to shift work history in a population-based case–control study in Spain. Methods This analysis included 1626 incident CRC cases and 3378 randomly selected population controls of both sexes, enrolled in 11 regions of Spain. Sociodemographic and lifestyle information was assessed in face-to-face interviews. Shift work was assessed in detail throughout lifetime occupational history. We estimated the risk of colon and rectal cancer associated with rotating and permanent shift work (ever, cumulative duration, age of first exposure) using unconditional logistic regression analysis adjusting for potential confounders. Results Having ever performed rotating shift work (morning, evening and/or night) was associated with an increased risk for CRC [odds ratio (OR) 1.22, 95% confidence interval (95% CI) 1.04–1.43], as compared to day workers. Having ever worked permanent night shifts (≥3 nights/month) was not associated with CRC risk (OR 0.79, 95% CI 0.62–1.00). OR increased with increasing lifetime cumulative duration of rotating shift work (P-value for trend 0.005) and were highest among subjects in the top quartiles of exposure (3rd quartile, 20–34 years, OR 1.38, 95%CI 1.06–1.81; 4th quartile, ≥35 years, OR 1.36, 95% CI 1.02–1.79). Conclusions These data suggest that rotating shift work may increase the risk of CRC especially after long-term exposures.
- dc.format.mimetype application/pdf
- dc.identifier.citation Papantoniou K, Castaño-Vinyals G, Espinosa A, Turner MC, Alonso-Aguado MH, Martin V, et al. Shift work and colorectal cancer risk in the MCC-Spain case–control study. Scand J Work Environ Health. 2017 May;43(3):250-9. DOI: 10.5271/sjweh.3626
- dc.identifier.doi http://dx.doi.org/10.5271/sjweh.3626
- dc.identifier.issn 0355-3140
- dc.identifier.uri http://hdl.handle.net/10230/60265
- dc.language.iso eng
- dc.publisher NOROSH
- dc.relation.ispartof Scandinavian Journal of Work, Environment & Health. 2017 May;43(3):250-9
- dc.rights This work is licensed under a Creative Commons Attribution 4.0 International License.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Cancer
- dc.subject.keyword Case-control study
- dc.subject.keyword Circadian disruption
- dc.subject.keyword Colon cancer
- dc.subject.keyword Colorectal cancer
- dc.subject.keyword Lifestyle
- dc.subject.keyword Night work
- dc.subject.keyword Prevention
- dc.subject.keyword Rectal cancer
- dc.subject.keyword Risk
- dc.subject.keyword Rotating shift work
- dc.subject.keyword Shift work
- dc.subject.keyword Shift worker
- dc.title Shift work and colorectal cancer risk in the MCC-Spain case-control study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion