Air pollution exposure during pregnancy and childhood, APOE ε4 status and Alzheimer polygenic risk score, and brain structural morphology in preadolescents

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Essers, Esmée
• dc.contributor.author Binter, Anne-Claire
• dc.contributor.author Neumann, Alexander
• dc.contributor.author White, Tonya
• dc.contributor.author Alemany, Silvia
• dc.contributor.author Guxens Junyent, Mònica
• dc.date.accessioned 2023-02-28T07:15:14Z
• dc.date.available 2023-02-28T07:15:14Z
• dc.date.issued 2023
• dc.description.abstract Background: Air pollution exposure is associated with impaired neurodevelopment, altered structural brain morphology in children, and neurodegenerative disorders. Differential susceptibility to air pollution may be influenced by genetic features. Objectives: To evaluate whether the apolipoprotein E (APOE) genotype or the polygenic risk score (PRS) for Alzheimer's Disease (AD) modify the association between air pollution exposure during pregnancy and childhood and structural brain morphology in preadolescents. Methods: We included 1186 children from the Generation R Study. Concentrations of fourteen air pollutants were calculated at participants' home addresses during pregnancy and childhood using land-use-regression models. Structural brain images were collected at age 9-12 years to assess cortical and subcortical brain volumes. APOE status and PRS for AD were examined as genetic modifiers. Linear regression models were used to conduct single-pollutant and multi-pollutant (using the Deletion/Substitution/Addition algorithm) analyses with a two-way interaction between air pollution and each genetic modifier. Results: Higher pregnancy coarse particulate matter (PMcoarse) and childhood polycyclic aromatic hydrocarbons exposure was differentially associated with larger cerebral white matter volume in APOE ε4 carriers compared to non-carriers (29,485 mm3 (95% CI 6,189; 52,781) and 18,663 mm3 (469; 36,856), respectively). Higher pregnancy PMcoarse exposure was differentially associated with larger cortical grey matter volume in children with higher compared to lower PRS for AD (19436 mm3 (825, 38,046)). Discussion: APOE status and PRS for AD possibly modify the association between air pollution exposure and brain structural morphology in preadolescents. Higher air pollution exposure is associated with larger cortical volumes in APOE ε4 carriers and children with a high PRS for AD. This is in line with typical brain development, suggesting an antagonistic pleiotropic effect of these genetic features (i.e., protective effect in early-life, but neurodegenerative effect in adulthood). However, we cannot discard chance findings. Future studies should evaluate trajectorial brain development using a longitudinal design.
• dc.format.mimetype application/pdf
• dc.identifier.citation Essers E, Binter AC, Neumann A, White T, Alemany S, Guxens M. Air pollution exposure during pregnancy and childhood, APOE ε4 status and Alzheimer polygenic risk score, and brain structural morphology in preadolescents. Environmental Research. 2023 Jan 1;216(Pt 2):114595. DOI: 10.1016/j.envres.2022.114595
• dc.identifier.doi http://dx.doi.org/10.1016/j.envres.2022.114595
• dc.identifier.issn 0013-9351
• dc.identifier.uri http://hdl.handle.net/10230/55943
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environmental Research. 2023 Jan 1;216(Pt 2):114595
• dc.rights © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Apolipoprotein E
• dc.subject.keyword Cohort study
• dc.subject.keyword Environmental pollution
• dc.subject.keyword Genetic modifiers
• dc.subject.keyword Neurodevelopment
• dc.subject.keyword Neuroimaging
• dc.title Air pollution exposure during pregnancy and childhood, APOE ε4 status and Alzheimer polygenic risk score, and brain structural morphology in preadolescents
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion