Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort
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- dc.contributor.author Sánchez Benavides, Gonzalo
- dc.contributor.author Gispert López, Juan Domingo
- dc.contributor.author Fauria, Karine
- dc.contributor.author Molinuevo, José Luis
- dc.contributor.author Gramunt Fombuena, Nina
- dc.date.accessioned 2025-01-13T08:31:08Z
- dc.date.available 2025-01-13T08:31:08Z
- dc.date.issued 2016
- dc.description.abstract Introduction. Repetitive administration of neuropsychological tests can lead to performance improvement merely due to previous exposure. The magnitude of such practice effects (PEs) may be used as a marker of subtle cognitive impairment because they are diminished in healthy individuals subsequently developing Alzheimer's disease (AD). Methods. To explore the relationship between sociodemographic factors, AD family history (FH), and APOE ε4 status, and the magnitude of PE, four subtests of the Wechsler Adult Intelligence Scale-IV were administered twice to 400 middle-aged healthy individuals, most of them first-degree descendants of AD patients. Results. PEs were observed in all measures. Sociodemographic variables did not show a uniform effect on PE. Baseline score was the strongest predictor of change, being inversely related to PE magnitude. Significant effects of the interaction term APOE ε4∗Age in processing speed and working memory were observed. Discussion. PEs exert a relevant effect in cognitive outcomes at retest and, accordingly, they must be taken into consideration in clinical trials. The magnitude of PE in processing speed and working memory could be of special interest for the development of cognitive markers of preclinical AD.en
- dc.format.mimetype application/pdf
- dc.identifier.citation Sánchez‐Benavides G, Gispert JD, Fauria K, Molinuevo JL, Gramunt N. Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort. Alzheimers Dement (Amst). 2016 Jan;4(1):149-58. DOI: 10.1016/j.dadm.2016.07.001
- dc.identifier.doi http://dx.doi.org/10.1016/j.dadm.2016.07.001
- dc.identifier.issn 2352-8729
- dc.identifier.uri http://hdl.handle.net/10230/69054
- dc.language.iso eng
- dc.publisher Wiley
- dc.relation.ispartof Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2016 Jan;4(1):149-58
- dc.rights © 2016 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Alzheimer's diseaseen
- dc.subject.keyword Preclinicalen
- dc.subject.keyword Cognitionen
- dc.subject.keyword Practice effectsen
- dc.subject.keyword APOEen
- dc.subject.keyword Family historyen
- dc.title Modeling practice effects in healthy middle‐aged participants of the Alzheimer and Families parent cohort
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion