Obstetric complications and genetic risk for schizophrenia: differential role of antenatal and perinatal events in first episode psychosis

Valli, Isabel; González Segura, Àlex; Verdolini, Norma; García-Rizo, Clemente; Berge Baquero, Daniel; Baeza, Immaculada; Cuesta, Manuel J.; Gonzalez-Pinto, Ana; Lobo, Antonio; Martinez-Aran, Anabel; Mezquida, Gisela; Pina-Camacho, Laura; Roldan Bejarano, Alexandra; Mas, Sergi; McGuire, Philip; Bernardo, Miquel; Vieta, Eduard; PEPs Group

Obstetric complications and genetic risk for schizophrenia: differential role of antenatal and perinatal events in first episode psychosis

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dc.contributor.author Valli, Isabel
dc.contributor.author González Segura, Àlex
dc.contributor.author Verdolini, Norma
dc.contributor.author García-Rizo, Clemente
dc.contributor.author Berge Baquero, Daniel
dc.contributor.author Baeza, Immaculada
dc.contributor.author Cuesta, Manuel J.
dc.contributor.author Gonzalez-Pinto, Ana
dc.contributor.author Lobo, Antonio
dc.contributor.author Martinez-Aran, Anabel
dc.contributor.author Mezquida, Gisela
dc.contributor.author Pina-Camacho, Laura
dc.contributor.author Roldan Bejarano, Alexandra
dc.contributor.author Mas, Sergi
dc.contributor.author McGuire, Philip
dc.contributor.author Bernardo, Miquel
dc.contributor.author Vieta, Eduard
dc.contributor.author PEPs Group
dc.date.accessioned 2023-09-06T06:36:18Z
dc.date.available 2023-09-06T06:36:18Z
dc.date.issued 2023
dc.description.abstract Background: Obstetric complications (OCs) are key contributors to psychosis risk. However, it is unclear whether they increase psychosis vulnerability independently of genetic risk, in interaction with it, or are a manifestation of psychosis proneness. We examined the role of distinct types of OCs in terms of psychosis risk and tested whether they interact differently with genetic vulnerability, whilst accounting for other known environmental risk factors. Study design: 405 participants (219 first episode psychosis patients and 186 healthy volunteers) underwent a comprehensive assessment of OCs, measured using the Lewis-Murray scale and divided into complications of pregnancy, abnormalities of foetal growth and development, and complications of delivery. Participants were compared in terms of history of OCs, polygenic risk score for schizophrenia (PRS-SZ) and interactions between these. Results: Both complications of pregnancy and abnormalities of foetal growth were significantly associated with case-control status (p = 0.02 and 0.03, respectively), whereas complications of delivery were not. PRS-SZ showed a significant association with psychosis (p = 0.04), but there were no significant interactions between genetic risk for schizophrenia and OCs, either when these were considered globally or separated based on their timeframe. Conclusions: We observed no significant interaction between genetic and obstetric vulnerability, yet distinct types of OCs may have a different impact on psychosis risk, based on their nature and timeframe. Examining their differential role might clarify their relative contributions to this risk.
dc.description.sponsorship This work was supported by the Ministerio de Economía y Competitividad (PI08/0208, PI11/00325, PI14/00612, PI20/00661); Instituto de Salud Carlos III – Fondo Europeo de Desarrollo Regional co-funded by the European Union; Centro de Investigación Biomédica en Red de salud Mental, CIBERSAM, ISCIII; by the CERCA Programme/Generalitat de Catalunya AND Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement (2017SGR1355). IV and NV were supported by the BITRECS project, which received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754550 and from “La Caixa” Foundation (ID 100010434), under the agreement LCF/PR/GN18/50310006.
dc.format.mimetype application/pdf
dc.identifier.citation Valli I, Gonzalez Segura A, Verdolini N, Garcia-Rizo C, Berge D, Baeza I, Cuesta MJ, Gonzalez-Pinto A, Lobo A, Martinez-Aran A, Mezquida G, Pina-Camacho L, Roldan Bejarano A, Mas S, McGuire P, Bernardo M, Vieta E, PEPs group. Obstetric complications and genetic risk for schizophrenia: differential role of antenatal and perinatal events in first episode psychosis. Acta Psychiatr Scand. 2023;148(1):81-90. DOI: 10.1111/acps.13546
dc.identifier.doi http://dx.doi.org/10.1111/acps.13546
dc.identifier.issn 0001-690X
dc.identifier.uri http://hdl.handle.net/10230/57819
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Acta Psychiatr Scand. 2023;148(1):81-90
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/754550
dc.rights © 2023 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Funding
dc.subject.keyword Environmental
dc.subject.keyword Placenta
dc.subject.keyword Polygenic risk score
dc.subject.keyword Pregnancy
dc.subject.keyword Utero
dc.title Obstetric complications and genetic risk for schizophrenia: differential role of antenatal and perinatal events in first episode psychosis
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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