Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study
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- dc.contributor.author Vilalta Lacarra, Anna
- dc.contributor.author Vilalta-Franch, Joan
- dc.contributor.author Serrano-Sarbosa, Domènec
- dc.contributor.author Martí-Lluch, Ruth
- dc.contributor.author Marrugat de la Iglesia, Jaume
- dc.contributor.author Garre-Olmo, Josep
- dc.date.accessioned 2024-05-14T06:19:13Z
- dc.date.available 2024-05-14T06:19:13Z
- dc.date.issued 2023
- dc.description.abstract Objective: This study aimed to assess the association of somatic depressive symptoms (SDS), cognitive/emotional depressive symptoms (C-EDS), and antidepressant treatment on mortality due to cancer and other causes in a community cohort. Methods: A community-based sample recruited in 1995, 2000, and 2005 aged between 35 and 75 years was examined in two waves and followed for a median of 6.7 years. SDS and C-EDS phenotypes were assessed using the Patient Health Questionnaire-9. Medication used by participants was collected. Deaths and their causes were registered during follow-up. Cox proportional hazard models stratified by sex were performed to determine the association between depressive phenotypes and mortality. Results: The cohort consisted of 5,646 individuals (53.9% women) with a mean age of 64 years (SD = 11.89). During the follow-up, 392 deaths were recorded, of which 27.8% were due to cancer. C-EDS phenotype was associated with an increased risk of cancer mortality in both men (HR = 2.23; 95% CI = 1.11-4.44) and women (HR = 3.69; 95% CI = 1.69-8.09), and SDS was significantly associated with non-cancer mortality in men (HR = 2.16; 95 CI % = 1.46-3.18). Selective serotonin reuptake inhibitors (SSRIs) were significantly associated with both cancer (HR = 2.78; 95% CI = 1.10-6.98) and non-cancer mortality (HR = 2.94; 95% CI = 1.76-4.90) only in the male population. Conclusion: C-EDS phenotype was related to an increased risk of cancer mortality at 6 years. In addition, the use of SSRIs in the male population was associated with cancer and all-cause mortality.
- dc.format.mimetype application/pdf
- dc.identifier.citation Vilalta-Lacarra A, Vilalta-Franch J, Serrano-Sarbosa D, Martí-Lluch R, Marrugat J, Garre-Olmo J. Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study. Front Psychol. 2023 Aug 24;14:1192462. DOI: 10.3389/fpsyg.2023.1192462
- dc.identifier.doi http://dx.doi.org/10.3389/fpsyg.2023.1192462
- dc.identifier.issn 1664-1078
- dc.identifier.uri http://hdl.handle.net/10230/60127
- dc.language.iso eng
- dc.publisher Frontiers
- dc.relation.ispartof Front Psychol. 2023 Aug 24;14:1192462
- dc.rights © 2023 Vilalta-Lacarra, Vilalta-Franch, Serrano-Sarbosa, Martí-Lluch, Marrugat and Garre-Olmo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. http://creativecommons.org/licenses/by/4.0/
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Antidepressant drug
- dc.subject.keyword Cancer
- dc.subject.keyword Depressive syndrome
- dc.subject.keyword Mortality
- dc.subject.keyword Somatic symptoms
- dc.title Association of depression phenotypes and antidepressant treatment with mortality due to cancer and other causes: a community-based cohort study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion