Natural selection in the great apes

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• dc.contributor.author Cagan, Alexanderca
• dc.contributor.author Theunert, Christophca
• dc.contributor.author Laayouni, Hafid, 1968-ca
• dc.contributor.author Santpere Baró, Gabriel, 1981-ca
• dc.contributor.author Pybus Oliveras, Marc, 1985-ca
• dc.contributor.author Casals López, Ferranca
• dc.contributor.author Prüfer, Kayca
• dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-ca
• dc.contributor.author Marquès i Bonet, Tomàs, 1975-ca
• dc.contributor.author Bertranpetit, Jaume, 1952-ca
• dc.contributor.author Andrés Morán, Aida, 1976-ca
• dc.date.accessioned 2017-10-23T15:26:58Z
• dc.date.available 2017-10-23T15:26:58Z
• dc.date.issued 2016
• dc.description.abstract Natural selection is crucial for the adaptation of populations to their environments. Here, we present the first global study of natural selection in the Hominidae (humans and great apes) based on genome-wide information from population samples representing all extant species (including most subspecies). Combining several neutrality tests we create a multi-species map of signatures of natural selection covering all major types of natural selection. We find that the estimated efficiency of both purifying and positive selection varies between species and is significantly correlated with their long-term effective population size. Thus, even the modest differences in population size among the closely related Hominidae lineages have resulted in differences in their ability to remove deleterious alleles and to adapt to changing environments. Most signatures of balancing and positive selection are species-specific, with signatures of balancing selection more often being shared among species. We also identify loci with evidence of positive selection across several lineages. Notably, we detect signatures of positive selection in several genes related to brain function, anatomy, diet and immune processes. Our results contribute to a better understanding of human evolution by putting the evidence of natural selection in humans within its larger evolutionary context. The global map of natural selection in our closest living relatives is available as an interactive browser at http://tinyurl.com/nf8qmzh.
• dc.description.sponsorship This work was supported by funding from the Max Planck Society to K.P. and A.M.A.; by grants from the Ministerio de Economía y Competitividad in Spain (grant BFU2013-43726-P) and the Secretaria d’Universitats i Recerca de la Generalitat de Catalunya (grant GRC 2014 SGR 866) to J.B.; by an European Research Council Advanced Grant (233297) to S.Pääbo and European Research Council Starting Grant (260372) to T.M.B.; and by European Molecular Biology Organization Young Investigator Award and Ministerio de Ciencia e Innovación in Spain (BFU2014-55090-P) to T.M.B.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Cagan A, Theunert C, Laayouni H, Santpere G, Pybus M, Casals F, Prüfer K, Navarro A, Marques-Bonet T, Bertranpetit J, Andrés AM. Natural selection in the great apes. Mol Biol Evol. 2016 Dec;33(12):3268-3283. DOI: 10.1093/molbev/msw215
• dc.identifier.doi http://dx.doi.org/10.1093/molbev/msw215
• dc.identifier.issn 1537-1719
• dc.identifier.uri http://hdl.handle.net/10230/33066
• dc.language.iso eng
• dc.publisher Oxford University Pressca
• dc.relation.ispartof Molecular Biology and Evolution. 2016 Dec;33(12):3268-83
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/233297
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/260372
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-55090-P
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2013-43726-P
• dc.rights © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Comparative genomics
• dc.subject.keyword Adaptation
• dc.subject.keyword Primates
• dc.subject.keyword Evolution
• dc.title Natural selection in the great apesca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion