Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning

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  • dc.contributor.author Castellá, Moisés
  • dc.contributor.author Blasco-Roset, Albert
  • dc.contributor.author Peyrou, Marion
  • dc.contributor.author Gavaldà-Navarro, Aleix
  • dc.contributor.author Villarroya, Joan
  • dc.contributor.author Quesada-López, Tania
  • dc.contributor.author Lorente-Poch, Leyre
  • dc.contributor.author Sancho Insenser, Juan
  • dc.contributor.author Szymczak, Florian
  • dc.contributor.author Piron, Anthony
  • dc.contributor.author Rodríguez-Fernández, Sonia
  • dc.contributor.author Carobbio, Stefania
  • dc.contributor.author Goday Arno, Alberto
  • dc.contributor.author Domingo, Pere
  • dc.contributor.author Vidal-Puig, Antonio
  • dc.contributor.author Giralt, Marta
  • dc.contributor.author Eizirik, Décio L.
  • dc.contributor.author Villarroya, Francesc
  • dc.contributor.author Cereijo, Rubén
  • dc.date.accessioned 2024-03-08T07:05:45Z
  • dc.date.available 2024-03-08T07:05:45Z
  • dc.date.issued 2023
  • dc.description.abstract Adipose tissue from pheochromocytoma patients acquires brown fat features, making it a valuable model for studying the mechanisms that control thermogenic adipose plasticity in humans. Transcriptomic analyses revealed a massive downregulation of splicing machinery components and splicing regulatory factors in browned adipose tissue from patients, with upregulation of a few genes encoding RNA-binding proteins potentially involved in splicing regulation. These changes were also observed in cell culture models of human brown adipocyte differentiation, confirming a potential involvement of splicing in the cell-autonomous control of adipose browning. The coordinated changes in splicing are associated with a profound modification in the expression levels of splicing-driven transcript isoforms for genes involved in the specialized metabolism of brown adipocytes and those encoding master transcriptional regulators of adipose browning. Splicing control appears to be a relevant component of the coordinated gene expression changes that allow human adipose tissue to acquire a brown phenotype.
  • dc.description.sponsorship We thank public funding source State Agency of Research (AEI) from the Spanish Ministry of Science (MCIN). Research supported by grant PID2020-114112RB-100 funded by MICIN/AEI/10.13039/50110 0011033. M.C. is an “Ayudas para contratos predoctorales” researcher (grant PRE2018-085231funded by the MCIN/AEI/10.13039/501100011033 and by by ESF Investing in your future). T.Q. is a “Juan de la Cierva-Incorporación” researcher (grant IJC2020-043380-I funded by the MCIN/AEI/10.13039/501100011033 and by the European Union NextGenerationEU/PRTR). R.C. is a “Juan de la Cierva-Incorporación” researcher (grant IJC2018-037142-I funded by the MCIN/AEI/10.13039/501100011033).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Castellá M, Blasco-Roset A, Peyrou M, Gavaldà-Navarro A, Villarroya J, Quesada-López T, Lorente-Poch L, Sancho J, Szymczak F, Piron A, Rodríguez-Fernández S, Carobbio S, Goday A, Domingo P, Vidal-Puig A, Giralt M, Eizirik DL, Villarroya F, Cereijo R. Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning. iScience. 2023 May 9;26(6):106847. DOI: 10.1016/j.isci.2023.106847
  • dc.identifier.doi http://dx.doi.org/10.1016/j.isci.2023.106847
  • dc.identifier.issn 2589-0042
  • dc.identifier.uri http://hdl.handle.net/10230/59354
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof iScience. 2023 May 9;26(6):106847
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-114112RB-100
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PRE2018-085231
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/IJC2020-043380-I
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/IJC2018-037142-I
  • dc.rights © 2023 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Biopsy sample
  • dc.subject.keyword Specialized functions of cells
  • dc.subject.keyword Transcriptomics
  • dc.title Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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