SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

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• dc.contributor.author Sancho-Shimizu, Vanessa
• dc.contributor.author Brodin, Petter
• dc.contributor.author Cobat, Aurélie
• dc.contributor.author Biggs, Catherine M.
• dc.contributor.author Toubiana, Julie
• dc.contributor.author Lucas, Carrie L.
• dc.contributor.author Henrickson, Sarah E.
• dc.contributor.author Belot, Alexandre
• dc.contributor.author MIS-C@CHGE
• dc.contributor.author Tangye, Stuart G.
• dc.contributor.author Milner, Joshua D.
• dc.contributor.author Levin, Michael
• dc.contributor.author Abel, Laurent
• dc.contributor.author Bogunovic, Dusan
• dc.contributor.author Casanova, Jean-Laurent
• dc.contributor.author Zhang, Shen-Ying
• dc.contributor.author Gut, Marta
• dc.date.accessioned 2022-05-17T10:57:42Z
• dc.date.available 2022-05-17T10:57:42Z
• dc.date.issued 2021
• dc.description.abstract Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses.
• dc.description.sponsorship The studies are funded by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (R01AI088364 to J.-L. Casanova and S.-Y. Zhang; R01AI148963, R01AI151029, and R01AI150300 to D. Bogunovic; K08AI135091 to S.E. Henrickson; R21AI144315-02S1 to C.L. Lucas), the National Center for Advancing Translational Sciences, National Institutes of Health Clinical and Translational Science Award program (UL1 TR001866), the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (UM1HG006504 and U24HG008956), Institut National de la Santé et de la Recherche Médicale and Université de Paris, the French National Research Agency (ANR) Résilience-Covid-19 grant GenMIS-C, the ANR “Investments for the Future” program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the ANR project AABIFNCOV (ANR-20-CO11-0001), the French Foundation for Medical Research (EQU201903007798), the French Foundation for Medical Research and ANR GENCOVID project, the ANRSCOV05 project, the Square Foundation, Grandir - Fonds de solidarité pour l’enfance, the Fondation du Souffle, the SCOR Corporate Foundation for Science, UK Research and Innovation Future Leader’s Fellowship (MR/S032304/1), the NIHR Imperial Biomedical Research Centre at Imperial College Healthcare NHS Trust (70931), the Burroughs Wellcome Fund Career Awards for Medical Scientists
• dc.format.mimetype application/pdf
• dc.identifier.citation Sancho-Shimizu V, Brodin P, Cobat A, Biggs CM, Toubiana J, Carrie LL et al. SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease? J Exp Med. 2021 Jun 7;218(6):e20210446. DOI:10.1084/jem.20210446
• dc.identifier.doi http://dx.doi.org/10.1084/jem.20210446
• dc.identifier.issn 1540-9538
• dc.identifier.uri http://hdl.handle.net/10230/53114
• dc.language.iso eng
• dc.publisher Rockefeller University Press
• dc.rights © 2021 Vanessa Sancho-Shimizu et al. This article is distributed under the terms of a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/4.0/
• dc.subject.other COVID-19 (Malaltia)
• dc.subject.other Malaltia de Kawasaki
• dc.subject.other Genètica
• dc.subject.other Pediatria
• dc.title SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion