Healthcare resource utilization in advanced non-small-cell lung cancer: post hoc analysis of the randomized phase 3 REVEL study

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Garon, Edward B.
• dc.contributor.author Winfree, Katherine B.
• dc.contributor.author Molife, Cliff
• dc.contributor.author Cui, Zhanglin Lin
• dc.contributor.author Arriola Aperribay, Edurne
• dc.contributor.author Levy, Benjamin
• dc.contributor.author Mekhail, Tarek
• dc.contributor.author Pérol, Maurice
• dc.date.accessioned 2021-01-08T08:01:29Z
• dc.date.available 2021-01-08T08:01:29Z
• dc.date.issued 2021
• dc.description.abstract Purpose: In REVEL, patients with advanced non-small-cell lung cancer (aNSCLC) and patients with increased tumor aggressiveness (rapid disease progression (RDP), platinum-refractory disease (PRD), and high symptom burden (HSB)) benefited from second-line treatment with ramucirumab plus docetaxel over placebo plus docetaxel. This post hoc analysis describes healthcare resource utilization (HCRU) associated with the treatment. Methods: aNSCLC patients who had progressed during or after first-line platinum-based chemotherapy were randomized to receive docetaxel and either ramucirumab or placebo until disease progression, unacceptable toxicity, withdrawal, or death. HCRU included hospitalizations, transfusions, and concomitant medications. Categorical variables (counts and percentages) were compared using Fisher's exact test. Continuous variables (mean, standard deviation (SD), median, minimum, and maximum) were compared using the Wilcoxon rank sum test. Results: Patient characteristics were largely similar between treatment arms. Within the intent-to-treat (ITT) population (n = 1253), the mean treatment duration was 19.7 and 16.9 weeks in the ramucirumab and control arms, respectively; 51.0% versus 54.9% of patients received subsequent anticancer therapy, respectively. Hospitalization rates were 41.9% versus 42.6% (p = 0.863), mean length of hospital stay was 14.5 days versus 11.3 days (p = 0.066), transfusion rates were 9.9% versus 12.3% (p = 0.206), and use of granulocyte colony-stimulating factors was 41.8% versus 36.6% (p = 0.063), respectively. No significant difference was observed in HCRU between treatment arms in both ITT population and in aggressive disease subgroups including RDP (n = 209), PRD (n = 360), and HSB (n = 497). Conclusion: In REVEL, the addition of ramucirumab to docetaxel did not increase HCRU among patients with aggressive aNSCLC disease. These results may help inform economic evaluation of treatment for patients with aNSCLC.
• dc.format.mimetype application/pdf
• dc.identifier.citation Garon EB, Winfree KB, Molife C, Cui ZL, Arriola E, Levy B, et al. Healthcare resource utilization in advanced non-small-cell lung cancer: post hoc analysis of the randomized phase 3 REVEL study. Support Care Cancer. 2021 Jan;29(1):117-25. DOI: 10.1007/s00520-020-05459-0
• dc.identifier.doi http://dx.doi.org/10.1007/s00520-020-05459-0
• dc.identifier.issn 0941-4355
• dc.identifier.uri http://hdl.handle.net/10230/46125
• dc.language.iso eng
• dc.publisher SpringerOpen
• dc.rights This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Aggressive disease
• dc.subject.keyword Docetaxel
• dc.subject.keyword Healthcare resource utilization
• dc.subject.keyword Non-small-cell lung cancer
• dc.subject.keyword Ramucirumab
• dc.title Healthcare resource utilization in advanced non-small-cell lung cancer: post hoc analysis of the randomized phase 3 REVEL study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion