Systematic review protocol to define classical IgE-associated diseases from birth to adolescence: the MeDALL study

Pinart, Mariona; Gimeno Santos, Elena, 1980-; García Aymerich, Judith; Guerra, Stefano; Benet, Marta; Jacquemin Leonard, Bénédicte; Kogevinas, Manolis; Lavi, Iris; Sunyer Deu, Jordi; Antó i Boqué, Josep Maria

Systematic review protocol to define classical IgE-associated diseases from birth to adolescence: the MeDALL study

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dc.contributor.author Pinart, Marionaca
dc.contributor.author Gimeno Santos, Elena, 1980-ca
dc.contributor.author García Aymerich, Judithca
dc.contributor.author Guerra, Stefanoca
dc.contributor.author Benet, Martaca
dc.contributor.author Jacquemin Leonard, Bénédicteca
dc.contributor.author Kogevinas, Manolisca
dc.contributor.author Lavi, Irisca
dc.contributor.author Sunyer Deu, Jordica
dc.contributor.author Antó i Boqué, Josep Mariaca
dc.date.accessioned 2014-05-21T11:08:48Z
dc.date.available 2014-05-21T11:08:48Z
dc.date.issued 2012ca
dc.description.abstract BACKGROUND: Classical disease phenotypes are mainly based on descriptions of symptoms and the hypothesis that a given pattern of symptoms provides a diagnosis. With refined technologies there is growing evidence that disease expression in patients is much more diverse and subtypes need to be defined to allow a better targeted treatment. One of the aims of the Mechanisms of the Development of Allergy Project (MeDALL,FP7) is to re-define the classical phenotypes of IgE-associated allergic diseases from birth to adolescence, by consensus among experts using a systematic review of the literature and identify possible gaps in research for new disease markers. This paper describes the methods to be used for the systematic review of the classical IgE-associated phenotypes applicable in general to other systematic reviews also addressing phenotype definitions based on evidence. METHODS/DESIGN: Eligible papers were identified by PubMed search (complete database through April 2011). This search yielded 12,043 citations. The review includes intervention studies (randomized and clinical controlled trials) and observational studies (cohort studies including birth cohorts, case-control studies) as well as case series. Systematic and non-systematic reviews, guidelines, position papers and editorials are not excluded but dealt with separately. Two independent reviewers in parallel conducted consecutive title and abstract filtering scans. For publications where title and abstract fulfilled the inclusion criteria the full text was assessed. In the final step, two independent reviewers abstracted data using a pre-designed data extraction form with disagreements resolved by discussion among investigators. DISCUSSION: The systematic review protocol described here allows to generate broad,multi-phenotype reviews and consensus phenotype definitions. The in-depth analysis of the existing literature on the classification of IgE-associated allergic diseases through such a systematic review will 1) provide relevant information on the current epidemiologic definitions of allergic diseases, 2) address heterogeneity and interrelationships and 3) identify gaps in knowledge.
dc.description.sponsorship This work was supported by the European Commission’s Seventh Framework Programme under grant/nagreement No. 261357 (Mechanisms of the Development of ALLergy, Framework Programme 7 N° 264357/n(MeDALL paper N°7)
dc.format.mimetype application/pdfca
dc.identifier.citation Pinart M, Maier D, Gimeno-santos E, Sola I, Garcia-aymerich J, Guerra S et al. Systematic review protocol to define classical IgE-associated diseases from birth to adolescence: the MeDALL study. WebmedCentral ALLERGY. 2012;3(5):1-20ca
dc.identifier.issn 2046-1690ca
dc.identifier.uri http://hdl.handle.net/10230/22499
dc.language.iso engca
dc.publisher WebmedCentralca
dc.relation.ispartof WebmedCentral ALLERGY. 2012;3(5):1-20
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357ca
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/264357
dc.rights © Pinart M, Maier D, Gimeno-santos E, Sola I, Garcia-aymerich J, Guerra S et al. Systematic review protocol to define classical IgE-associated diseases from birth to adolescence: the MeDALL study. WebmedCentral ALLERGY. 2012; 3(5): 1-20. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any mediumca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.rights.uri http://creativecommons.org/licenses/by/3.0/
dc.subject.other Immunoglobulina E
dc.subject.other Al·lèrgia en els infants
dc.subject.other Adolescents -- Malalties
dc.subject.other Al·lèrgia
dc.title Systematic review protocol to define classical IgE-associated diseases from birth to adolescence: the MeDALL studyca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Departament de Medicina i Ciències de la Vida)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)