Coevolution trumps pleiotropy: carbon assimilation traits are independent of metabolic network structure in budding yeast

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• dc.contributor.author Opulente, Dana A.ca
• dc.contributor.author Morales, Christopher M.ca
• dc.contributor.author Carey, Lucas, 1980-ca
• dc.contributor.author Rest, Joshua S.ca
• dc.date.accessioned 2015-06-02T08:11:04Z
• dc.date.available 2015-06-02T08:11:04Z
• dc.date.issued 2013ca
• dc.description.abstract Phenotypic traits may be gained and lost together because of pleiotropy, the involvement of common genes and networks, or because of simultaneous selection for multiple traits across environments (multiple-trait coevolution). However, the extent to which network pleiotropy versus environmental coevolution shapes shared responses has not been addressed. To test these alternatives, we took advantage of the fact that the genus Saccharomyces has variation in habitat usage and diversity in the carbon sources that a given strain can metabolize. We examined patterns of gain and loss in carbon utilization traits across 488 strains of Saccharomyces to investigate whether the structure of metabolic pathways or selection pressure from common environments may have caused carbon utilization traits to be gained and lost together. While most carbon sources were gained and lost independently of each other, we found four clusters that exhibit non-random patterns of gain and loss across strains. Contrary to the network pleiotropy hypothesis, we did not find that these patterns are explained by the structure of metabolic pathways or shared enzymes. Consistent with the hypothesis that common environments shape suites of phenotypes, we found that the environment a strain was isolated from partially predicts the carbon sources it can assimilate.en
• dc.description.sponsorship This work was supported by startup funds from Stony Brook University to JR.en
• dc.format.mimetype application/pdfca
• dc.identifier.citation Opulente DA, Morales CM, Carey LB, Rest JS. Coevolution trumps pleiotropy: carbon assimilation traits are independent of metabolic network structure in budding yeast. PLoS One. 2013;8(1):e54403. DOI: 10.1371/journal.pone.0054403ca
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0054403
• dc.identifier.issn 1932-6203ca
• dc.identifier.uri http://hdl.handle.net/10230/23708
• dc.language.iso engca
• dc.publisher Public Library of Science (PLoS)ca
• dc.relation.ispartof PLoS One. 2013;8(1):e54403
• dc.rights © 2013 Opulente et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.other Molèculesca
• dc.subject.other Saccharomyces cerevisiae -- Metabolismeca
• dc.title Coevolution trumps pleiotropy: carbon assimilation traits are independent of metabolic network structure in budding yeasten
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca