Snail1 is required for the maintenance of the pancreatic acinar phenotype
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- dc.contributor.author Loubat Casanovas, Jordina, 1982-ca
- dc.contributor.author Peña, Raúlca
- dc.contributor.author Gonzàlez Busqué, Núria, 1980-ca
- dc.contributor.author Alba Castellón, Lorena, 1984-ca
- dc.contributor.author Rosell, Santica
- dc.contributor.author Francí i Carreté, Claraca
- dc.contributor.author Navarro Medrano, Pilarca
- dc.contributor.author García de Herreros, Antonioca
- dc.date.accessioned 2016-04-18T11:35:05Z
- dc.date.available 2016-04-18T11:35:05Z
- dc.date.issued 2016
- dc.description.abstract The Snail1 transcriptional factor is required for correct embryonic development, yet its expression in adult animals is very limited and its functional roles are not evident. We have now conditionally inactivated Snail1 in adult mice and analyzed the phenotype of these animals. Snail1 ablation rapidly altered pancreas structure: one month after Snail1 depletion, acinar cells were markedly depleted, and pancreas accumulated adipose tissue. Snail1 expression was not detected in the epithelium but was in pancreatic mesenchymal cells (PMCs). Snail1 ablation in cultured PMCs downregulated the expression of several β-catenin/Tcf-4 target genes, modified the secretome of these cells and decreased their ability to maintain acinar markers in cultured pancreas cells. Finally, Snail1 deficiency modified the phenotype of pancreatic tumors generated in transgenic mice expressing c-myc under the control of the elastase promoter. Specifically, Snail1 depletion did not significantly alter the size of the tumors but accelerated acinar-ductal metaplasia. These results demonstrate that Snail1 is expressed in PMCs and plays a pivotal role in maintaining acinar cells within the pancreas in normal and pathological conditions.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Loubat-Casanovas J, Peña R, Gonzàlez N, Alba-Castellón L, Rosell S, Francí C et al. Snail1 is required for the maintenance of the pancreatic acinar phenotype. Oncotarget. 2016;7(4):4468-82. DOI: 10.18632/oncotarget.6785ca
- dc.identifier.doi http://dx.doi.org/10.18632/oncotarget.6785
- dc.identifier.issn 1949-2553
- dc.identifier.uri http://hdl.handle.net/10230/26107
- dc.language.iso engca
- dc.publisher Impact Journalsca
- dc.relation.ispartof Oncotarget. 2016;7(4):4468-82
- dc.rights © The Authors. This is the published version of an article http://dx.doi.org/10.18632/oncotarget.6785 that appeared in the journal Oncotarget. It is published under a Creative Commons Attribution 3.0 Licenseca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/3.0/ca
- dc.subject.keyword Snail1
- dc.subject.keyword Acinar-ductal metaplasia
- dc.subject.keyword Fibroblast activation
- dc.subject.keyword Pancreas physiology
- dc.subject.keyword Pancreatic mesenchymal cells
- dc.subject.other Pàncreesca
- dc.title Snail1 is required for the maintenance of the pancreatic acinar phenotypeca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca