A novel approach to high-quality postmortem tissue procurement: The GTEx Project

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• dc.contributor.author Carithers, Latarsha J.ca
• dc.contributor.author Guigó Serra, Rodericca
• dc.contributor.author GTEx Consortiumca
• dc.date.accessioned 2016-04-19T14:21:20Z
• dc.date.available 2016-04-19T14:21:20Z
• dc.date.issued 2015
• dc.description.abstract The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and tissue-specific gene expression in non-diseased individuals. A significant challenge was the collection of high-quality biospecimens for extensive genomic analyses. Here we describe how a successful infrastructure for biospecimen procurement was developed and implemented by multiple research partners to support the prospective collection, annotation, and distribution of blood, tissues, and cell lines for the GTEx project. Other research projects can follow this model and form beneficial partnerships with rapid autopsy and organ procurement organizations to collect high quality biospecimens and associated clinical data for genomic studies. Biospecimens, clinical and genomic data, and Standard Operating Procedures guiding biospecimen collection for the GTEx project are available to the research community.ca
• dc.description.sponsorship This work was supported by the National Institutes of Health (HHSN261200800001E (Leidos Prime contract with NCI); 10XS170 (NDRI), 10XS171 (Roswell Park Cancer Institute), 10X172 (Science Care Inc.), 12ST1039 (IDOX); 10ST1035 (Van Andel Institute); HHSN268201000029C (Broad Institute); and R01 DA006227-17 (U Miami Brain Bank).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Carithers LJ, Ardlie K, Barcus M, Branton PA, Britton A, Buia SA et al. A novel approach to high-quality postmortem tissue procurement: The GTEx Project. Biopreservation and biobanking. 2015;13(5):311-9. DOI: 10.1089/bio.2015.0032ca
• dc.identifier.doi http://dx.doi.org/10.1089/bio.2015.0032
• dc.identifier.issn 1947-5535
• dc.identifier.uri http://hdl.handle.net/10230/26127
• dc.language.iso engca
• dc.publisher Mary Ann Liebert, Incca
• dc.relation.ispartof Biopreservation and biobanking. 2015;13(5):311-9
• dc.rights © The Author(s) 2015; Published by Mary Ann Liebert, Inc. This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are creditedca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ca
• dc.subject.other Expressió gènicaca
• dc.title A novel approach to high-quality postmortem tissue procurement: The GTEx Projectca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca