Early life exposures contributing to accelerated lung function decline in adulthood - a follow-up study of 11,000 adults from the general population

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  • dc.contributor.author Kirkeleit, Jorunn
  • dc.contributor.author Carsin, Anne-Elie
  • dc.contributor.author García Aymerich, Judith
  • dc.contributor.author Svanes, Cecilie
  • dc.date.accessioned 2024-03-18T07:43:18Z
  • dc.date.available 2024-03-18T07:43:18Z
  • dc.date.issued 2023
  • dc.description.abstract Background: We aimed to assess whether exposure to risk factors in early life from conception to puberty continue to contribute to lung function decline later in life by using a pooled cohort comprising approx. 11,000 adults followed for more than 20 years and with up to three lung function measurements. Methods: Participants (20-68 years) in the ECRHS and NFBC1966 cohort studies followed in the periods 1991-2013 and 1997-2013, respectively, were included. Mean annual decline in maximum forced expired volume in 1 s (FEV1) and forced vital capacity (FVC) were main outcomes. Associations between early life risk factors and change in lung function were estimated using mixed effects linear models adjusted for sex, age, FEV1, FVC and height at baseline, accounting for personal smoking. Findings: Decline in lung function was accelerated in participants with mothers that smoked during pregnancy (FEV1 2.3 ml/year; 95% CI: 0.7, 3.8) (FVC 2.2 ml/year; 0.2, 4.2), with asthmatic mothers (FEV1 2.6 ml/year; 0.9, 4.4) (FEV1/FVC 0.04 per year; 0.04, 0.7) and asthmatic fathers (FVC 2.7 ml/year; 0.5, 5.0), and in women with early menarche (FVC 2.4 ml/year; 0.4, 4.4). Personal smoking of 10 pack-years contributed to a decline of 2.1 ml/year for FEV1 (1.8, 2.4) and 1.7 ml/year for FVC (1.3, 2.1). Severe respiratory infections in early childhood were associated with accelerated decline among ever-smokers. No effect-modification by personal smoking, asthma symptoms, sex or cohort was found. Interpretation: Mothers' smoking during pregnancy, parental asthma and early menarche may contribute to a decline of FEV1 and FVC later in life comparable to smoking 10 pack-years. Funding: European Union's Horizon 2020; Research Council of Norway; Academy of Finland; University Hospital Oulu; European Regional Development Fund; Spanish Ministry of Science and Innovation; Generalitat de Catalunya.
  • dc.description.sponsorship This study was funded by the European Union's Horizon 2020 research and innovation program under grant agreement number 633212 (Ageing Lungs in European Cohorts study) and grant agreement number 874703 (The Exposome Project for Health and Occupational Research), as well as by the Research Council of Norway under grant number 274767 (Preconception exposures and related epigenetic mechanisms in asthma and allergies). NFBC1966 received financial support related to the present work from the Academy of Finland (EGEA-project, 285547), University Hospital Oulu, Biocenter, University of Oulu, Finland and ERDF European Regional Development Fund Grant no. 539/2010 A31592, and EU H2020-SC1-2016-2017 LIFECYCLE Action Grant no 633212 and EU H2020-CS1-2018-2019 EUCAN-Connect Action, Grant no 824989. ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and from the Generalitat de Catalunya through the CERCA Program. The funding sources did not have any role in designing the study, collection, analysis, and interpretation of data, in the writing of the manuscript or in the decision to submit the paper for publication.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Kirkeleit J, Riise T, Wielscher M, Accordini S, Carsin AE, Dratva J, et al. Early life exposures contributing to accelerated lung function decline in adulthood - a follow-up study of 11,000 adults from the general population. EClinicalMedicine. 2023 Dec 8;66:102339. DOI: 10.1016/j.eclinm.2023.102339
  • dc.identifier.doi http://dx.doi.org/10.1016/j.eclinm.2023.102339
  • dc.identifier.issn 2589-5370
  • dc.identifier.uri http://hdl.handle.net/10230/59447
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof EClinicalMedicine. 2023 Dec 8;66:102339
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/633212
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874703
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/824989
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
  • dc.rights © 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Accelerated decline
  • dc.subject.keyword Early life risk factors
  • dc.subject.keyword FEV1
  • dc.subject.keyword FEV1/FVC ratio
  • dc.subject.keyword FVC
  • dc.subject.keyword Lung function
  • dc.subject.keyword Maternal asthma
  • dc.subject.keyword Maternal smoking
  • dc.subject.keyword Paternal asthma
  • dc.title Early life exposures contributing to accelerated lung function decline in adulthood - a follow-up study of 11,000 adults from the general population
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)