Role of maternal Vitamin D3 levels in shaping adolescent vascular health: Evidence from a spanish population-based birth cohort

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• dc.contributor.author Sangüesa, Júlia
• dc.contributor.author Márquez, Sandra
• dc.contributor.author Montazeri, Parisa, 1988-
• dc.contributor.author Fochs, Silvia
• dc.contributor.author Pey, Núria
• dc.contributor.author Anguita Ruiz, Augusto
• dc.contributor.author Warembourg, Charline
• dc.contributor.author Rouxel, Elke
• dc.contributor.author Nawrot, Tim S.
• dc.contributor.author De Boever, Patrick
• dc.contributor.author Elen, Bart
• dc.contributor.author Clemente Batalha Pardal, Diana, 1990-
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author Vrijheid, Martine
• dc.date.accessioned 2025-05-13T06:06:35Z
• dc.date.available 2025-05-13T06:06:35Z
• dc.date.issued 2025
• dc.description.abstract Background: Low gestational vitamin D levels may increase offspring risk of cardiovascular disease from an early age. Studies investigating the impact on offspring macrovascular function have been inconsistent. Few included pulse wave velocity as an arterial stiffness indicator, and none included measures of microvascularization as an early marker of cardiovascular health. This study explored the association between gestational vitamin D levels and macro- and microvascular health across early adolescence. Methods and results: We analyzed data from 430 mother-child pairs from a Spanish birth cohort. 25-hydroxyvitamin D3 (vitamin D3) levels were measured in serum at 13 weeks of pregnancy. At 11 and 15 years we assessed macrovascular parameters, including systolic and diastolic blood pressure (mm Hg) and pulse wave velocity (m/s), and microvascular parameters (central retinal artery/vein equivalent (μm)). We used continuous (in ng/mL) and categorical (deficient <20 ng/mL versus adequate >20 ng/mL) deseasonalized 25(OH)D3 levels as exposure. Mixed effect and linear regression models were conducted. During their pregnancies, nearly 23% of the mothers had deficient vitamin D3 levels. We did not find statistically significant associations between pregnancy vitamin D3 levels and macro- and microvascular function markers across adolescence. However, subjects exposed to deficient vitamin D3 levels showed a nonstatistically significant decrease in pulse wave velocity (β=-0.09 [95% CI, -0.19 to 0.01]) compared with those exposed to adequate levels. There was no evidence of a sex interaction. Conclusions: Our findings show little evidence to support associations between low vitamin D levels during pregnancy and macro- or microvascular health parameters through early adolescence.
• dc.description.sponsorship Júlia Sangüesa holds a PFIS (Personal Formación de Investigadores en Salud) fellowship, funded by the Instituto de Salud Carlos III (Spanish Health Research Institute) through the project “FI19/00124” (co‐funded by the European Social Fund, “Investing in your future”). ISGlobal (Barcelona Institute for Global Health) acknowledges support from the grant CEX2023‐0001290‐S funded by the Spanish Ministry of Science and Innovation (MCIN) and the State Research Agency (MCIN/AEI/https://doi.org/10.13039/501100011033), and support from the Generalitat de Catalunya (Government of Catalonia) through the CERCA Program. The INMA‐Sabadell cohort was funded by grants from the Instituto de Salud Carlos III (Spanish Health Research Institute) through multiple initiatives (including Red INMA, Childhood and Environment Network, grant G03/176; and CIBERESP, Network for Biomedical Research in Epidemiology and Public Health), from the Generalitat de Catalunya‐CIRIT (Interdepartmental Commission for Research and Technological Innovation; grant 1999SGR 00241), and from the Generalitat de Catalunya‐AGAUR (Agency for Management of University and Research Grants; grants 2009 SGR 501 and 2014 SGR 822). Additional support was provided by Fundació La Marató de TV3 (Marató Foundation; grant 090430), the Spanish Ministry of Economy and Competitiveness MINECO (grant SAF2012‐32991, co‐funded by the European Regional Development Fund [FEDER]), and the Agence Nationale de Sécurité Sanitaire de l'Alimentation, de l'Environnement et du Travail (ANSES; grants 1262C0010, EST‐2016 RF‐21, EST‐19 RF‐04, and 2019/1/233). The study also received funding from the European Commission through several projects (261357, 308333, 603794, 634453, 825712, and 874583).
• dc.format.mimetype application/pdf
• dc.identifier.citation Sangüesa J, Márquez S, Montazeri P, Fochs S, Pey N, Anguita-Ruiz A, et al. Role of maternal Vitamin D3 levels in shaping adolescent vascular health: Evidence from a spanish population-based birth cohort. J Am Heart Assoc. 2025 Mar 4;14(5):e035273. DOI: 10.1161/JAHA.124.035273
• dc.identifier.doi http://dx.doi.org/10.1161/JAHA.124.035273
• dc.identifier.issn 2047-9980
• dc.identifier.uri http://hdl.handle.net/10230/70361
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof J Am Heart Assoc. 2025 Mar 4;14(5):e035273
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012‐32991
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
• dc.rights © 2025 The Author(s). Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Adolescence
• dc.subject.keyword Arterial stiffness
• dc.subject.keyword Blood pressure
• dc.subject.keyword Cardiovascular health
• dc.subject.keyword Pregnancy
• dc.subject.keyword Retinal microcirculation
• dc.subject.keyword Vitamin D
• dc.subject.keyword info:eu-repo/grantAgreement/EC/H2020/634453
• dc.subject.keyword info:eu-repo/grantAgreement/EC/H2020/825712
• dc.subject.keyword info:eu-repo/grantAgreement/EC/H2020/874583
• dc.title Role of maternal Vitamin D3 levels in shaping adolescent vascular health: Evidence from a spanish population-based birth cohort
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion