Cancer signaling transcriptome is upregulated in type 2 diabetes mellitus

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• dc.contributor.author Almanza-Aguilera, Enrique
• dc.contributor.author Hernáez, Álvaro
• dc.contributor.author Corella, Dolores
• dc.contributor.author Sanllorente Melenchón, Albert
• dc.contributor.author Ros, Emilio
• dc.contributor.author Portolés, Olga
• dc.contributor.author Valussi, Julieta
• dc.contributor.author Estruch, Ramón
• dc.contributor.author Coltell, Oscar
• dc.contributor.author Subirana Cachinero, Isaac
• dc.contributor.author Canudas i Puig, Sílvia
• dc.contributor.author Razquin, Cristina
• dc.contributor.author Blanchart, Gemma
• dc.contributor.author Nonell Mazelon, Lara, 1972-
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Castañer, Olga
• dc.date.accessioned 2021-10-14T06:47:55Z
• dc.date.available 2021-10-14T06:47:55Z
• dc.date.issued 2020
• dc.description.abstract We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis of 19 individuals with T2D and 15 without. Differentially expressed genes according to linear models were submitted to the Ingenuity Pathway Analysis system to conduct a functional enrichment analysis. We established that diseases, biological functions, and canonical signaling pathways were significantly associated with T2D patients when their logarithms of Benjamini-Hochberg-adjusted p-value were >1.30 and their absolute z-scores were >2.0 (≥2.0 meant "upregulation" and ≤ -2.0 "downregulation"). Cancer signaling pathways were the most upregulated ones in T2D (z-score = 2.63, -log(p-value) = 32.3; 88.5% (n = 906) of the total differentially expressed genes located in these pathways). In particular, integrin (z-score = 2.52, -log(p-value) = 2.03) and paxillin (z-score = 2.33, -log(p-value) = 1.46) signaling pathways were predicted to be upregulated, whereas the Rho guanosine diphosphate (Rho-GDP) dissociation inhibitor signaling pathway was predicted to be downregulated in T2D individuals (z-score = -2.14, -log(p-value) = 2.41). Our results suggest that, at transcriptional expression level, elderly individuals with T2D present an increased activation of signaling pathways related to neoplastic processes, T-cell activation and migration, and inflammation.
• dc.format.mimetype application/pdf
• dc.identifier.citation Almanza-Aguilera E, Hernáez Á, Corella D, Sanllorente A, Ros E, Portolés O, et al. Cancer signaling transcriptome is upregulated in type 2 diabetes mellitus. Clin Med. 2020 Dec 29;10(1):85. DOI: 10.3390/jcm10010085
• dc.identifier.doi http://dx.doi.org/10.3390/jcm10010085
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/48651
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cancer
• dc.subject.keyword Microarray
• dc.subject.keyword Signaling pathways
• dc.subject.keyword Transcriptome
• dc.subject.keyword Type 2 diabetes
• dc.title Cancer signaling transcriptome is upregulated in type 2 diabetes mellitus
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion