Structural determinants of criticality in biological networks
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- dc.contributor.author Valverde, Sergica
- dc.contributor.author Ohse, Sebastianca
- dc.contributor.author Turalska, Malgorzataca
- dc.contributor.author West, Bruce J.ca
- dc.contributor.author García Ojalvo, Jordica
- dc.date.accessioned 2016-01-26T13:26:36Z
- dc.date.available 2016-01-26T13:26:36Z
- dc.date.issued 2015
- dc.description.abstract Many adaptive evolutionary systems display spatial and temporal features, such as long-range correlations, typically associated with the critical point of a phase transition in statistical physics. Empirical and theoretical studies suggest that operating near criticality enhances the functionality of biological networks, such as brain and gene networks, in terms for instance of information processing, robustness, and evolvability. While previous studies have explained criticality with specific system features, we still lack a general theory of critical behavior in biological systems. Here we look at this problem from the complex systems perspective, since in principle all critical biological circuits have in common the fact that their internal organization can be described as a complex network. An important question is how self-similar structure influences self-similar dynamics. Modularity and heterogeneity, for instance, affect the location of critical points and can be used to tune the system toward criticality. We review and discuss recent studies on the criticality of neuronal and genetic networks, and discuss the implications of network theory when assessing the evolutionary features of criticality.ca
- dc.description.sponsorship This paper was supported by the Spanish Ministry of Economy and Competitiveness (Grants FIS2013-44674-P and FIS2012-37655-C02-01) and FEDER and by the ICREA Academia programme (JGO). MT acknowledges support of the Army Research Office through grant W911NF-04-D-0001.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Valverde S, Ohse S, Turalska M, West BJ, Garcia-Ojalvo J. Structural determinants of criticality in biological networks. Frontiers in physiology. 2015;6:127. DOI: 10.3389/fphys.2015.00127ca
- dc.identifier.doi http://dx.doi.org/10.3389/fphys.2015.00127
- dc.identifier.issn 1664-042X
- dc.identifier.uri http://hdl.handle.net/10230/25660
- dc.language.iso engca
- dc.publisher Frontiersca
- dc.relation.ispartof Frontiers in physiology.2015;6:127
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/FIS2012-37655-C02-01
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/FIS2013-44674-P
- dc.rights © 2015 Valverde, Ohse, Turalska, West and Garcia-Ojalvo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Criticality
- dc.subject.keyword Evolution
- dc.subject.keyword Gene regulatory networks
- dc.subject.keyword Hierarchical modular networks
- dc.subject.keyword Neural networks
- dc.subject.keyword Power laws
- dc.subject.keyword Robustness
- dc.subject.other Regulació genèticaca
- dc.title Structural determinants of criticality in biological networksca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca