Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice

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• dc.contributor.author Aso Pérez, Esterca
• dc.contributor.author Balerio, Graciela N.ca
• dc.contributor.author Maldonado, Rafael, 1961-ca
• dc.date.accessioned 2011-07-27T08:27:44Z
• dc.date.available 2011-07-27T08:27:44Z
• dc.date.issued 2006ca
• dc.description.abstract Rationale: Acute behavioural effects and motivational responses induced by nicotine can be modulated by the endocannabinoid system supporting the existence of a physiological interaction between these two systems. Objectives: The present study was designed to examine the possible involvement of the cannabinoid system in the anxiolytic- and anxiogenic-like responses induced by nicotine in mice. Methods: Animals were only exposed once to nicotine. The acute administration of low (0.05, sc) or high (0.8 mg/kg, sc) doses of nicotine produced opposite effects in the elevated plus-maze, i.e., anxiolytic- and anxiogenic-like responses, respectively. The effects of the pretreatment with the CB1 cannabinoid receptor antagonist, rimonabant (0.25, 0.5 and 1 mg/kg, ip), and the cannabinoid agonist, 9-tetrahydrocannabinol (0.1 mg/kg, ip), were evaluated on the anxiolytic- and anxiogenic-like responses induced by nicotine. Results: Rimonabant completely abolished nicotine-induced anxiolytic-like effects and increased the anxiogenic-like responses of nicotine, suggesting an involvement of CB1 receptors in these behavioural responses. On the other hand, 9-tetrahydrocannabinol failed to modify nicotine anxiolytic-like responses, but attenuated its anxiogenic-like effects. In addition the association of non-effective doses of 9-tetrahydrocannabinol and nicotine produced clear anxiolytic-like responses. Conclusions: These results demonstrate that the endogenous cannabinoid system is involved in the regulation of nicotine anxiety-like behaviour in mice, and provide new findings to support the use of cannabinoid antagonists in the treatment of tobacco addiction.
• dc.description.sponsorship This work has been supported by grants from National Institutes of Health (1R01-DA016768-0111), Ministerio de Educación y Ciencia (BFU 2004–00920/BFI), Marató TV3, Redes de Centros y Grupos del Instituto de Salud Carlos III (C03/06 and G03/005), Generalitat de Catalunya (2002 SGR00193) and the European Comission (Quality of Life and Management of Living Resources QLRT-2001-01691 LSHM-CT 2004-005166). Graciela Balerio is a post doctoral fellow supported by “Fundación Carolina”.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Balerio GN, Aso E, Maldonado R. Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in mice. Psychopharmacology. 2006;184(3-4):504-13. DOI: 10.1007/s00213-005-0251-9
• dc.identifier.doi http://dx.doi.org/10.1007/s00213-005-0251-9
• dc.identifier.issn 0033-3158
• dc.identifier.uri http://hdl.handle.net/10230/12417
• dc.language.iso engca
• dc.publisher Springerca
• dc.relation.ispartof Psychopharmacology. 2006;184(3-4):504-13
• dc.rights © Springer. The original publication is available at www.springerlink.comca
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Nicotine
• dc.subject.keyword Cannabinoid system
• dc.subject.keyword Elevated plus-maze
• dc.subject.keyword Anxiety
• dc.subject.other Cannabinoides -- Receptors
• dc.subject.other Nicotina -- Efectes fisiològics
• dc.subject.other Nicotina -- Receptors
• dc.subject.other Cannabinoides -- Efectes fisiològics
• dc.title Role of the cannabinoid system in the effects induced by nicotine on anxiety-like behaviour in miceca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/submittedVersion