Phenotypic clustering in non-cystic fibrosis bronchiectasis patients: the role of eosinophils in disease severity

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• dc.contributor.author Wang, Xuejie
• dc.contributor.author Villa, Carmen
• dc.contributor.author Dobarganes, Yadira
• dc.contributor.author Olveira, Casilda
• dc.contributor.author Girón, Rosa
• dc.contributor.author García-Clemente, Marta
• dc.contributor.author Máiz, Luis
• dc.contributor.author Sibila, Oriol
• dc.contributor.author Golpe, Rafael
• dc.contributor.author Menéndez, Rosario
• dc.contributor.author Rodríguez-López, Juan
• dc.contributor.author Prados, Concepción
• dc.contributor.author Martínez-García, Miguel Ángel
• dc.contributor.author Rodriguez, Juan Luis
• dc.contributor.author Rosa, David de la
• dc.contributor.author Duran Jordà, Xavier, 1974-
• dc.contributor.author García Ojalvo, Jordi
• dc.contributor.author Barreiro Portela, Esther
• dc.date.accessioned 2021-10-14T06:21:35Z
• dc.date.available 2021-10-14T06:21:35Z
• dc.date.issued 2021
• dc.description.abstract Whether high blood eosinophil counts may define a better phenotype in bronchiectasis patients, as shown in chronic obstructive pulmonary disease (COPD), remains to be investigated. Differential phenotypic characteristics according to eosinophil counts were assessed using a biostatistical approach in a large cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 906 patients who met the inclusion criteria were clustered into two groups on the basis of their eosinophil levels. The potential differences according to the bronchiectasis severity index (BSI) score between two groups (Mann-Whitney U test and eosinophil count threshold: 100 cells/µL) showed the most balanced cluster sizes: above-threshold and below-threshold groups. Patients above the threshold exhibited significantly better clinical outcomes, lung function, and nutritional status, while showing lower systemic inflammation levels. The proportion of patients with mild disease was higher in the above-threshold group, while the below-threshold patients were more severe. Two distinct clinical phenotypes of stable patients with non-cystic fibrosis (CF) bronchiectasis of a wide range of disease severity were established on the basis of blood eosinophil counts using a biostatistical approach. Patients classified within the above-threshold cluster were those exhibiting a mild disease, significantly better clinical outcomes, lung function, and nutritional status while showing lower systemic inflammatory levels. These results will contribute to better characterizing bronchiectasis patients into phenotypic profiles with their clinical implications.
• dc.description.sponsorship This study was supported by FIS 18/00075, FIS 21/00215 (FEDER, ISC-III) & CIBERES (ISC-III), SEPAR 2020, and ZAMBON-PHARMA (Spain). JGO was supported by the Spanish Ministry of Science and Innovation and FEDER (project PGC 2018-101251-B-I00 and Maria de Maeztu Programme for Units of Excellence in R&D, grant CEX2018-000792-M) and by the Generalitat de Catalunya (ICREA Academia programme).
• dc.format.mimetype application/pdf
• dc.identifier.citation Wang X, Villa C, Dobarganes Y, Olveira C, Girón R, García-Clemente M, Máiz L, Sibila O, Golpe R, Menéndez R, Rodríguez-López J, Prados C, Martinez-García MA, Rodriguez JL, de la Rosa D, Duran X, Garcia-Ojalvo J, Barreiro E. Phenotypic clustering in non-cystic fibrosis bronchiectasis patients: the role of eosinophils in disease severity. Int J Environ Res Public Health. 2021;18(16):8431. DOI: 10.3390/ijerph18168431
• dc.identifier.doi http://dx.doi.org/10.3390/ijerph18168431
• dc.identifier.issn 1661-7827
• dc.identifier.uri http://hdl.handle.net/10230/48647
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Int J Environ Res Public Health. 2021;18(16):8431
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-101251-B-I00
• dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Biostatistical analyses
• dc.subject.keyword Clinical outcomes
• dc.subject.keyword Disease severity scores
• dc.subject.keyword Eosinophil counts
• dc.subject.keyword Multivariate analyses
• dc.subject.keyword Non-cystic fibrosis bronchiectasis
• dc.subject.keyword Phenotypic clusters
• dc.title Phenotypic clustering in non-cystic fibrosis bronchiectasis patients: the role of eosinophils in disease severity
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion