Biomedical and societal impacts of in vitro embryo models of mammalian development

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• dc.contributor.author Martínez Arias, Alfonso
• dc.contributor.author Alev, Cantas
• dc.contributor.author Pera, Martin
• dc.date.accessioned 2022-03-18T10:53:19Z
• dc.date.available 2022-03-18T10:53:19Z
• dc.date.issued 2021
• dc.description.abstract In recent years, a diverse array of in vitro cell-derived models of mammalian development have been described that hold immense potential for exploring fundamental questions in developmental biology, particularly in the case of the human embryo where ethical and technical limitations restrict research. These models open up new avenues toward biomedical advances in in vitro fertilization, clinical research, and drug screening with potential to impact wider society across many diverse fields. These technologies raise challenging questions with profound ethical, regulatory, and social implications that deserve due consideration. Here, we discuss the potential impacts of embryo-like models, and their biomedical potential and current limitations.
• dc.description.sponsorship The work of A.M.-A. and N.M. is supported by grants from the MRC (MR/R017190/1 and MR/V005367/1) and the Leverhulme Trust (RPG-2018-356), of C.A. by grants from the Japan Agency for Medical Research and Development (AMED) under grant number JP20bm0704050, the ASHBi Fusion Research Program, and ISHIZUE 2020 of Kyoto University Research Development Program
• dc.format.mimetype application/pdf
• dc.identifier.citation Moris N, Alev C, Pera M, Mart.inez Arias A. Biomedical and societal impacts of in vitro embryo models of mammalian development. Stem Cell Reports. 2021 May 11;16(5):1021-1030. DOI: 10.1016/j.stemcr.2021.03.023
• dc.identifier.doi http://dx.doi.org/10.1016/j.stemcr.2021.03.023
• dc.identifier.issn 2213-6711
• dc.identifier.uri http://hdl.handle.net/10230/52720
• dc.language.iso eng
• dc.publisher Elsevier
• dc.rights © 2021. Naomi Moris et al. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.other Embriologia
• dc.subject.other Fecundació in vitro -- Aspectes ètics i morals
• dc.title Biomedical and societal impacts of in vitro embryo models of mammalian development
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion