Risk of cognitive impairment in patients with parkinson’s disease with visual hallucinations and subjective cognitive complaints

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• dc.contributor.author Santos García, Diego
• dc.contributor.author Puente Periz, Victor Manuel
• dc.contributor.author COPPADIS Study Group
• dc.date.accessioned 2024-05-23T07:13:49Z
• dc.date.available 2024-05-23T07:13:49Z
• dc.date.issued 2023
• dc.description.abstract Background and purpose: Visual hallucinations (VH) and subjective cognitive complaints (SCC) are associated with cognitive impairment (CI) in Parkinson's disease. Our aims were to determine the association between VH and SCC and the risk of CI development in a cohort of patients with Parkinson's disease and normal cognition (PD-NC). Methods: Patients with PD-NC (total score of >80 on the Parkinson's Disease Cognitive Rating Scale [PD-CRS]) recruited from the Spanish COPPADIS cohort from January 2016 to November 2017 were followed up after 2 years. Subjects with a score of ≥1 on domain 5 and item 13 of the Non-Motor Symptoms Scale at baseline (V0) were considered as "with SCC" and "with VH," respectively. CI at the 2-year follow-up (plus or minus 1 month) (V2) was defined as a PD-CRS total score of <81. Results: At V0 (n=376, 58.2% males, age 61.14±8.73 years [mean±SD]), the frequencies of VH and SCC were 13.6% and 62.2%, respectively. VH were more frequent in patients with SCC than in those without: 18.8% (44/234) vs 4.9% (7/142), p<0.0001. At V2, 15.2% (57/376) of the patients had developed CI. VH presenting at V0 was associated with a higher risk of CI at V2 (odds ratio [OR]=2.68, 95% confidence interval=1.05-6.83, p=0.0.039) after controlling for the effects of age, disease duration, education, medication, motor and nonmotor status, mood, and PD-CRS total score at V0. Although SCC were not associated with CI at V2, presenting both VH and SCC at V0 increased the probability of having CI at V2 (OR=3.71, 95% confidence interval=1.36-10.17, p=0.011). Conclusions: VH were associated with the development of SCC and CI at the 2-year follow-up in patients with PD-NC.
• dc.format.mimetype application/pdf
• dc.identifier.citation Santos-García D, Deus Fonticoba T, Cores Bartolomé C, Feal Painceiras MJ, Paz González JM, Martínez Miró C, et al. Risk of cognitive impairment in patients with parkinson’s disease with visual hallucinations and subjective cognitive complaints. J Clin Neurol. 2023 Jul;19(4):344-57. DOI: 10.3988/jcn.2022.0186
• dc.identifier.doi http://dx.doi.org/10.3988/jcn.2022.0186
• dc.identifier.issn 1738-6586
• dc.identifier.uri http://hdl.handle.net/10230/60222
• dc.language.iso eng
• dc.publisher UNLISTED PUBLISHER
• dc.relation.ispartof J Clin Neurol. 2023 Jul;19(4):344-57
• dc.rights © 2023 Korean Neurological. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0
• dc.subject.keyword Cognitive impairment
• dc.subject.keyword Dementia
• dc.subject.keyword Parkinson's disease
• dc.subject.keyword Subjective cognitive complaints
• dc.subject.keyword Visual hallucinations
• dc.title Risk of cognitive impairment in patients with parkinson’s disease with visual hallucinations and subjective cognitive complaints
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion