Do redox balance and inflammatory events take place in mild bronchiectasis? a hint to clinical implications
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- dc.contributor.author Qin, Liyun
- dc.contributor.author Guitart, Maria
- dc.contributor.author Admetlló Papiol, Mireia
- dc.contributor.author Esteban-Cucó, Sandra
- dc.contributor.author Maiques Llácer, José María
- dc.contributor.author Xia, Yingchen
- dc.contributor.author Zha, Jianhua
- dc.contributor.author Carbullanca Toledo, Santiago
- dc.contributor.author Duran, Xavier
- dc.contributor.author Wang, Xuejie
- dc.contributor.author Barreiro Portela, Esther
- dc.date.accessioned 2022-06-20T07:01:55Z
- dc.date.available 2022-06-20T07:01:55Z
- dc.date.issued 2021
- dc.description.abstract We hypothesized that in mild bronchiectasis patients, increased systemic inflammation and redox imbalance may take place and correlate with clinical parameters. In plasma samples from patients with very mild bronchiectasis, inflammatory cells and molecules and redox balance parameters were analyzed. In the patients, lung function and exercise capacity, nutritional status, bacterial colonization, and radiological extension were assessed. Correlations between biological and clinical variables were determined. Compared to healthy controls, levels of acute phase reactants, neutrophils, IgG, IgA, myeloperoxidase, protein oxidation, and GSH increased and lung function and exercise capacity were mildly reduced. GSH levels were even greater in ex-smoker and Pseudomona-colonized patients. Furthermore, radiological extension inversely correlated with airway obstruction and, disease severity, and positively correlated with neutrophil numbers in mild bronchiectasis patients with no nutritional abnormalities. In stable patients with mild bronchiectasis, several important inflammatory and oxidative stress events take place in plasma. These findings suggest that the extension of bronchiectasis probably plays a role in the development of redox imbalance and systemic inflammation in patients with mild bronchiectasis. These results have therapeutic implications in the management of bronchiectasis patients.
- dc.format.mimetype application/pdf
- dc.identifier.citation Qin L, Guitart M, Admetlló M, Esteban-Cucó S, Maiques JM, Xia Y, et al. Do redox balance and inflammatory events take place in mild bronchiectasis? a hint to clinical implications. J Clin Med. 2021 Sep 30; 10(19): 4534. DOI: 10.3390/jcm10194534
- dc.identifier.doi http://dx.doi.org/10.3390/jcm10194534
- dc.identifier.issn 2077-0383
- dc.identifier.uri http://hdl.handle.net/10230/53531
- dc.language.iso eng
- dc.publisher MDPI
- dc.rights Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Acute phase reactants
- dc.subject.keyword Antioxidants
- dc.subject.keyword Bronchiectasis severity scores
- dc.subject.keyword Myeloperoxidase
- dc.subject.keyword Non-CF bronchiectasis patients
- dc.subject.keyword Prooxidants
- dc.subject.keyword Reduced glutathione
- dc.title Do redox balance and inflammatory events take place in mild bronchiectasis? a hint to clinical implications
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion