Readmissions and complications in breast ductal carcinoma in situ: A retrospective study comparing screen- and non-screen-detected patients

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  • dc.contributor.author Politi, Julieta
  • dc.contributor.author Sala Serra, Maria
  • dc.contributor.author Domingo Torrell, Laia
  • dc.contributor.author Vernet-Tomás, Maria
  • dc.contributor.author Román, Marta
  • dc.contributor.author Macià Guilà, Francesc Assís
  • dc.contributor.author Castells, Xavier
  • dc.date.accessioned 2021-05-31T07:32:18Z
  • dc.date.available 2021-05-31T07:32:18Z
  • dc.date.issued 2020
  • dc.description.abstract Objective: Population-wide mammographic screening programs aim to reduce breast cancer mortality. However, a broad view of the harms and benefits of these programs is necessary to favor informed decisions, especially in the earliest stages of the disease. Here, we compare the outcomes of patients diagnosed with breast ductal carcinoma in situ in participants and non-participants of a population-based mammographic screening program. Methods: A retrospective cohort study of all patients diagnosed with breast ductal carcinoma in situ between 2000 and 2010 within a single hospital. A total of 211 patients were included, and the median follow-up was 8.4 years. The effect of detection mode (screen-detected and non-screen-detected) on breast cancer recurrences, readmissions, and complications was evaluated through multivariate logistic regression analysis. Results: In the majority of women, breast ductal carcinoma in situ was screen-detected (63.5%). Screen-detected breast ductal carcinoma in situ was smaller in size compared to those non-screen-detected (57.53% < 20 mm versus 78.03%, p = 0.002). Overall, breast-conserving surgery was the most frequent surgery (86.26%); however, mastectomy was higher in non-screen-detected breast ductal carcinoma in situ (20.78% versus 9.7%, p = 0.024). Readmissions for mastectomy were more frequent in non-screen-detected breast ductal carcinoma in situ. Psychological complications, such as fatigue, anxiety, and depression, had a prevalence of 15% within our cohort. Risk of readmissions and complications was higher within the non-screen-detected group, as evidenced by an odds ratio = 6.25 (95% confidence interval = 1.95-19.99) for readmissions and an odds ratio = 2.41 (95% confidence interval = 1.95-4.86) for complications. Conclusions: Our findings indicate that women with breast ductal carcinoma in situ breast cancer diagnosed through population-based breast cancer screening program experience a lower risk of readmissions and complications than those diagnosed outside these programs. These findings can help aid women and health professionals make informed decisions regarding screening.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Politi J, Sala M, Domingo L, Vernet-Tomas M, Román M, Macià F, et al. Readmissions and complications in breast ductal carcinoma in situ: A retrospective study comparing screen- and non-screen-detected patients. Womens Health (Lond). 2020 Jan-Dec; 16: 1745506520965899. DOI: 10.1177/1745506520965899
  • dc.identifier.doi http://dx.doi.org/10.1177/1745506520965899
  • dc.identifier.issn 1745-5057
  • dc.identifier.uri http://hdl.handle.net/10230/47690
  • dc.language.iso eng
  • dc.publisher SAGE Publications
  • dc.rights Copyright © The Author(s) 2020. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.subject.keyword Breast ductal carcinoma in situ
  • dc.subject.keyword Hospital readmission
  • dc.subject.keyword Mastectomy
  • dc.subject.keyword Patient-relevant outcome
  • dc.subject.keyword Screening
  • dc.title Readmissions and complications in breast ductal carcinoma in situ: A retrospective study comparing screen- and non-screen-detected patients
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Hospital del Mar Research Institute)
Articles (Departament de Medicina i Ciències de la Vida)