Tandem chimeric transcription as a means to increase protein diversity in the human genome
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- dc.contributor.author Parra Farré, Genísca
- dc.contributor.author Reymond, Alexandreca
- dc.contributor.author Dabbouseh, Nouraca
- dc.contributor.author Dermitzakis, Emmanuouil T.ca
- dc.contributor.author Thomson, Timothy M.ca
- dc.contributor.author Antonarakis, Stylianos E.ca
- dc.contributor.author Guigó Serra, Rodericca
- dc.date.accessioned 2012-05-24T14:28:22Z
- dc.date.available 2012-05-24T14:28:22Z
- dc.date.issued 2006ca
- dc.description.abstract The “one-gene, one-protein” rule, coined by Beadle and Tatum, has been fundamental to molecular biology. The rule implies that the genetic complexity of an organism depends essentially on its gene number. The discovery, however, that alternative gene splicing and transcription are widespread phenomena dramatically altered our understanding of the genetic complexity of higher eukaryotic organisms; in these, a limited number of genes may potentially encode a much larger number of proteins. Here we investigate yet another phenomenon that may contribute to generate additional protein diversity. Indeed, by relying on both computational and experimental analysis, we estimate that at least 4%–5% of the tandem gene pairs in the human genome can be eventually transcribed into a single RNA sequence encoding a putative chimeric protein. While the functional significance of most of these chimeric transcripts remains to be determined, we provide strong evidence that this phenomenon does not correspond to mere technical artifacts and that it is a common mechanism with the potential of generating hundreds of additional proteins in the human genome.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Parra G, Reymond A, Dabbouseh N, Dermitzakis ET, Castelo R, Thomson TM et al. Tandem chimeric transcription as a means to increase protein diversity in the human genome. Genome Res. 2006;16(1):37–44. DOI: 10.1101/gr.4145906ca
- dc.identifier.doi http://dx.doi.org/10.1101/gr.4145906
- dc.identifier.issn 1088-9051ca
- dc.identifier.uri http://hdl.handle.net/10230/16485
- dc.language.iso engca
- dc.publisher Cold Spring Harbor Laboratory Press-CSHL Pressca
- dc.relation.ispartof Genome Research. 2006;16(1):37–44
- dc.rights © 2006 Genome Research by Cold Spring Harbor Laboratory Press. Published version available at http://genome.cshlp.org. Aquest document està subjecte a Llicència Creative Commons (Attribution-NonCommercial 3.0 Unported License)ca
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
- dc.subject.other Factors de transcripció
- dc.subject.other Genoma humà
- dc.subject.other Biologia molecular
- dc.subject.other Seqüències de nucleòtids
- dc.subject.other Interaccions ADN-proteïnes
- dc.title Tandem chimeric transcription as a means to increase protein diversity in the human genomeca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersion