Polygenic risk for ADHD and ASD and their relation with cognitive measures in school children

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• dc.contributor.author Aguilar Lacasaña, Sofía
• dc.contributor.author Vilor Tejedor, Natàlia, 1988-
• dc.contributor.author Jansen, Philip R.
• dc.contributor.author López Vicente, Mònica, 1988-
• dc.contributor.author Bustamante Pineda, Mariona
• dc.contributor.author Burgaleta Díaz, Miguel, 1981-
• dc.contributor.author Sunyer Deu, Jordi
• dc.contributor.author Alemany, Silvia
• dc.date.accessioned 2020-11-11T10:48:01Z
• dc.date.available 2020-11-11T10:48:01Z
• dc.date.issued 2020
• dc.description.abstract Background: Attention deficit and hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are child-onset neurodevelopmental disorders frequently accompanied by cognitive difficulties. In the current study, we aim to examine the genetic overlap between ADHD and ASD and cognitive measures of working memory (WM) and attention performance among schoolchildren using a polygenic risk approach. Methods: A total of 1667 children from a population-based cohort aged 7-11 years with data available on genetics and cognition were included in the analyses. Polygenic risk scores (PRS) were calculated for ADHD and ASD using results from the largest GWAS to date (N = 55 374 and N = 46 351, respectively). The cognitive outcomes included verbal and numerical WM and the standard error of hit reaction time (HRTSE) as a measure of attention performance. These outcomes were repeatedly assessed over 1-year period using computerized version of the Attention Network Test and n-back task. Associations were estimated using linear mixed-effects models. Results: Higher polygenic risk for ADHD was associated with lower WM performance at baseline time but not over time. These findings remained significant after adjusting by multiple testing and excluding individuals with an ADHD diagnosis but were limited to boys. PRS for ASD was only nominally associated with an increased improvement on verbal WM over time, although this association did not survive multiple testing correction. No associations were observed for HRTSE. Conclusions: Common genetic variants related to ADHD may contribute to worse WM performance among schoolchildren from the general population but not to the subsequent cognitive-developmental trajectory assessed over 1-year period.
• dc.description.sponsorship This work was supported by the European Research Council under the Grant Agreement number 268479 - the BREATHE project. ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the ‘Centro de Excelencia Severo Ochoa 2019-2023’ Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. S.Alemany and N.Vilor-Tejedor are funded by Juan de la Cierva Programme (Ministry of Science, Innovation and Universities - Spanish State Research Agency, ref. IJCI-2017-34068, and ref. FJC-2018-038085-I).
• dc.format.mimetype application/pdf
• dc.identifier.citation Aguilar-Lacasaña S, Vilor-Tejedor N, Jansen PR, López-Vicente M, Bustamante M, Burgaleta M, Sunyer J, Alemany S. Polygenic risk for ADHD and ASD and their relation with cognitive measures in school children. Psychol Med. 2022 May;52(7):1356-64. DOI: 10.1017/S0033291720003189
• dc.identifier.doi http://dx.doi.org/10.1017/S0033291720003189
• dc.identifier.issn 0033-2917
• dc.identifier.uri http://hdl.handle.net/10230/45722
• dc.language.iso eng
• dc.publisher Cambridge University Press
• dc.relation.ispartof Psychol Med. 2022 May;52(7):1356-64
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/268479
• dc.rights © The Author(s), 2020. Published by Cambridge University Press This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword ADHD
• dc.subject.keyword ASD
• dc.subject.keyword Cognition
• dc.subject.keyword Polygenic risk score
• dc.subject.keyword Working memory
• dc.title Polygenic risk for ADHD and ASD and their relation with cognitive measures in school children
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion