4D reconstruction of murine developmental trajectories using spherical harmonics
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- dc.contributor.author Dalmasso, Giovanni
- dc.contributor.author Musy, Marco
- dc.contributor.author Niksic, Martina
- dc.contributor.author Robert Moreno, Alexandre
- dc.contributor.author Badía Careaga, Claudio
- dc.contributor.author Sanz-Ezquerro, Juan José
- dc.contributor.author Sharpe, James
- dc.date.accessioned 2022-10-26T06:25:37Z
- dc.date.available 2022-10-26T06:25:37Z
- dc.date.issued 2022
- dc.description.abstract Normal organogenesis cannot be recapitulated in vitro for mammalian organs, unlike in species including Drosophila and zebrafish. Available 3D data in the form of ex vivo images only provide discrete snapshots of the development of an organ morphology. Here, we propose a computer-based approach to recreate its continuous evolution in time and space from a set of 3D volumetric images. Our method is based on the remapping of shape data into the space of the coefficients of a spherical harmonics expansion where a smooth interpolation over time is simpler. We tested our approach on mouse limb buds and embryonic hearts. A key advantage of this method is that the resulting 4D trajectory can take advantage of all the available data while also being able to interpolate well through time intervals for which there are little or no data. This allows for a quantitative, data-driven 4D description of mouse limb morphogenesis.
- dc.description.sponsorship This research was supported by core funding from EMBL and CRG, and also the ERC advanced grant SIMBIONT (project no. 670555) and a grant from the Fundacion La Marato TV3 (grant 082030). G.D. and M.M. were supported by the ERC advanced grant SIMBIONT (project no. 670555).
- dc.format.mimetype application/pdf
- dc.identifier.citation Dalmasso G, Musy M, Niksic M, Robert-Moreno A, Badía-Careaga C, Sanz-Ezquerro JJ, Sharpe J. 4D reconstruction of murine developmental trajectories using spherical harmonics. Dev Cell. 2022 Sep 12;57(17):2140-50.e5. DOI: 10.1016/j.devcel.2022.08.005
- dc.identifier.doi http://dx.doi.org/10.1016/j.devcel.2022.08.005
- dc.identifier.issn 1534-5807
- dc.identifier.uri http://hdl.handle.net/10230/54591
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Dev Cell. 2022 Sep 12;57(17):2140-50.e5
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/670555
- dc.rights © 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword OPT
- dc.subject.keyword Heart growth
- dc.subject.keyword Limb growth
- dc.subject.keyword Morphogenesis
- dc.subject.keyword Mouse development
- dc.subject.keyword Spherical harmonics
- dc.subject.keyword Voxel data
- dc.title 4D reconstruction of murine developmental trajectories using spherical harmonics
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion