Antithetic population response to antibiotics in a polybacterial community

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  • dc.contributor.author Galera Laporta, Letícia, 1985-
  • dc.contributor.author García Ojalvo, Jordi
  • dc.date.accessioned 2020-03-10T08:25:13Z
  • dc.date.available 2020-03-10T08:25:13Z
  • dc.date.issued 2020
  • dc.description.abstract Much is known about the effects of antibiotics on isolated bacterial species, but their influence on polybacterial communities is less understood. Here, we study the joint response of a mixed community of nonresistant Bacillus subtilis and Escherichia coli bacteria to moderate concentrations of the β-lactam antibiotic ampicillin. We show that when the two organisms coexist, their population response to the antibiotic is opposite to that in isolation: Whereas in monoculture B. subtilis is tolerant and E. coli is sensitive to ampicillin, in coculture it is E. coli who can proliferate in the presence of the antibiotic, while B. subtilis cannot. This antithetic behavior is predicted by a mathematical model constrained only by the responses of the two species in isolation. Our results thus show that the collective response of mixed bacterial ecosystems to antibiotics can run counter to what single-species potency studies tell us about their efficacy.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Galera-Laporta L, Garcia-Ojalvo J. Antithetic population response to antibiotics in a polybacterial community. Science Advances. 2020; 6(10):eaaz5108. DOI: 10.1126/sciadv.aaz5108
  • dc.identifier.doi http://dx.doi.org/10.1126/sciadv.aaz5108
  • dc.identifier.issn 2375-2548
  • dc.identifier.uri http://hdl.handle.net/10230/43845
  • dc.language.iso eng
  • dc.publisher American Association for the Advancement of Science (AAAS)
  • dc.relation.ispartof Science Advances. 2020; 6(10):eaaz5108
  • dc.rights Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial of License 4.0 (CC BY-NC).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.title Antithetic population response to antibiotics in a polybacterial community
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Departament de Medicina i Ciències de la Vida)