Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature
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- dc.contributor.author Servello, Francesco A.
- dc.contributor.author Fernandes, Rute
- dc.contributor.author Eder, Matthias
- dc.contributor.author Harris, Nathan
- dc.contributor.author Martin, Olivier M. F.
- dc.contributor.author Oswal, Natasha
- dc.contributor.author Lindberg, Anders
- dc.contributor.author Derosiers, Nohelly
- dc.contributor.author Sengupta, Piali
- dc.contributor.author Stroustrup, Nicholas
- dc.contributor.author Apfeld, Javier
- dc.date.accessioned 2023-01-20T07:48:08Z
- dc.date.available 2023-01-20T07:48:08Z
- dc.date.issued 2022
- dc.description.abstract Hydrogen peroxide is the most common reactive chemical that organisms face on the microbial battlefield. The rate with which hydrogen peroxide damages biomolecules required for life increases with temperature, yet little is known about how organisms cope with this temperature-dependent threat. Here, we show that Caenorhabditis elegans nematodes use temperature information perceived by sensory neurons to cope with the temperature-dependent threat of hydrogen peroxide produced by the pathogenic bacterium Enterococcus faecium. These nematodes preemptively induce the expression of specific hydrogen peroxide defenses in response to perception of high temperature by a pair of sensory neurons. These neurons communicate temperature information to target tissues expressing those defenses via an insulin/IGF1 hormone. This is the first example of a multicellular organism inducing their defenses to a chemical when they sense an inherent enhancer of the reactivity of that chemical.
- dc.format.mimetype application/pdf
- dc.identifier.citation Servello FA, Fernandes R, Eder M, Harris N, Martin OMF, Oswal N, Lindberg A, Derosiers N, Sengupta P, Stroustrup N, Apfeld J. Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature. Elife. 2022 Oct 13;11:e78941. DOI: 10.7554/eLife.78941
- dc.identifier.doi http://dx.doi.org/10.7554/eLife.78941
- dc.identifier.issn 2050-084X
- dc.identifier.uri http://hdl.handle.net/10230/55347
- dc.language.iso eng
- dc.publisher eLife
- dc.relation.ispartof Elife. 2022 Oct 13;11:e78941
- dc.rights © 2022, Servello et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword C. elegans
- dc.subject.keyword E. coli
- dc.subject.keyword Enterococcus faecium
- dc.subject.keyword Developmental biology
- dc.subject.keyword Hydrogen peroxide
- dc.subject.keyword Insulin signaling
- dc.subject.keyword Neuroscience
- dc.subject.keyword Sensory perception
- dc.subject.keyword Temperature
- dc.title Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion