The endocannabinoid system in guarding against fear, anxiety and stress
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- dc.contributor.author Lutz, Beatca
- dc.contributor.author Marsicano, Giovannica
- dc.contributor.author Maldonado, Rafael, 1961-ca
- dc.contributor.author Hillard, Cecilia J.ca
- dc.date.accessioned 2018-06-04T07:45:15Z
- dc.date.available 2018-06-04T07:45:15Z
- dc.date.issued 2015
- dc.description.abstract The endocannabinoid (eCB) system has emerged as a central integrator linking the perception of external and internal stimuli to distinct neurophysiological and behavioural outcomes (such as fear reaction, anxiety and stress-coping), thus allowing an organism to adapt to its changing environment. eCB signalling seems to determine the value of fear-evoking stimuli and to tune appropriate behavioural responses, which are essential for the organism's long-term viability, homeostasis and stress resilience; and dysregulation of eCB signalling can lead to psychiatric disorders. An understanding of the underlying neural cell populations and cellular processes enables the development of therapeutic strategies to mitigate behavioural maladaptation.
- dc.description.sponsorship B.L. was supported by the German Research Foundation (SFB TRR 58, CRC 1080 and FOR 926); G.M. by the Institut national de la santé et de la recherche médicale (INSERM), the European Commission Seventh Framework Programme (REPROBESITY, HEALTH-F2-2008-223713, PAINCAGE and HEALTH-2014-603191), the European Research Council (Endofood, ERC-2010-StG−260515, CannaPreg and ERC-2014-PoC-640923), the Fondation pour la Recherche Medicale (DRM20101220445), the Human Frontiers Science Program, Region Aquitaine, Agence Nationale de la Recherche (ANR Blanc NeuroNutriSens ANR-13-BSV4-0006 and BRAIN ANR-10-LABX-0043); R.M. by the grants SAF2014-59648P, RETICS-RTA#RD12/0028/0023, AGAUR#2014-SGR-1547 and Health-F2-2013-602891; and C.J.H. by the US National Institutes of Health grants DA038663, DA026996 and MH102838.
- dc.format.mimetype application/pdf
- dc.identifier.citation Lutz B, Marsicano G, Maldonado R, Hillard CJ. The endocannabinoid system in guarding against fear, anxiety and stress. Nat Rev Neurosci. 2015 Dec; 16(12): 705-18. DOI: 10.1038/nrn4036
- dc.identifier.doi http://dx.doi.org/10.1038/nrn4036
- dc.identifier.issn 1471-003X
- dc.identifier.uri http://hdl.handle.net/10230/34794
- dc.language.iso eng
- dc.publisher Nature Publishing Groupca
- dc.relation.ispartof Nature Reviews Neuroscience. 2015 Dec;16(12):705-18
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/223713
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603191
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/260515
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/640923
- dc.relation.projectID info:eu-repo/grantAgreement/ES/SAF2014-59648-P
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/602891
- dc.rights © Nature Publishing Group. http://dx.doi.org/10.1038/nrn4036
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Amygdala
- dc.subject.keyword Anxiety
- dc.subject.keyword Fear conditioning
- dc.subject.keyword Stress and resilience
- dc.subject.keyword Synaptic plasticity
- dc.title The endocannabinoid system in guarding against fear, anxiety and stressca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion