Mixtures of long-term exposure to ambient air pollution, built environment and temperature and stroke incidence across Europe

Bont, Jeroen de; Pickford, Regina; Astrom, Christopher; Colomar, Fabian; Dimakopoulou, Konstantina; Hoogh, Kees de; Ibi, Dorina; Katsouyanni, Klea; Melén, Erik; Nobile, Federica; Pershagen, Göran; Persson, Åsa; Samoli, Evangelia; Stafoggia, Massimo; Tonne, Cathryn; Vlaanderen, Jelle; Wolf, Kathrin; Vermeulen, Roel; Peters, Annette; Ljungman, Petter

Mixtures of long-term exposure to ambient air pollution, built environment and temperature and stroke incidence across Europe

Mostra el registre complet Registre parcial de l'ítem

dc.contributor.author Bont, Jeroen de
dc.contributor.author Pickford, Regina
dc.contributor.author Astrom, Christopher
dc.contributor.author Colomar, Fabian
dc.contributor.author Dimakopoulou, Konstantina
dc.contributor.author Hoogh, Kees de
dc.contributor.author Ibi, Dorina
dc.contributor.author Katsouyanni, Klea
dc.contributor.author Melén, Erik
dc.contributor.author Nobile, Federica
dc.contributor.author Pershagen, Göran
dc.contributor.author Persson, Åsa
dc.contributor.author Samoli, Evangelia
dc.contributor.author Stafoggia, Massimo
dc.contributor.author Tonne, Cathryn
dc.contributor.author Vlaanderen, Jelle
dc.contributor.author Wolf, Kathrin
dc.contributor.author Vermeulen, Roel
dc.contributor.author Peters, Annette
dc.contributor.author Ljungman, Petter
dc.date.accessioned 2023-11-07T07:28:11Z
dc.date.available 2023-11-07T07:28:11Z
dc.date.issued 2023
dc.description.abstract Introduction: The complex interplay of multiple environmental factors and cardiovascular has scarcely been studied. Within the EXPANSE project, we evaluated the association between long-term exposure to multiple environmental indices and stroke incidence across Europe. Methods: Participants from three traditional adult cohorts (Germany, Netherlands and Sweden) and four administrative cohorts (Catalonia [region Spain], Rome [city-wide], Greece and Sweden [nationwide]) were followed until incident stroke, death, migration, loss of follow-up or study end. We estimated exposures at residential addresses from different exposure domains: air pollution (nitrogen dioxide (NO2), particulate matter < 2.5 μm (PM2.5), black carbon (BC), ozone), built environment (green/blue spaces, impervious surfaces) and meteorology (seasonal mean and standard deviation of temperatures). Associations between environmental exposures and stroke were estimated in single and multiple-exposure Cox proportional hazard models, and Principal Component (PC) Analyses derived prototypes for specific exposures domains. We carried out random effects meta-analyses by cohort type. Results: In over 15 million participants, increased levels of NO2 and BC were associated with increased higher stroke incidence in both cohort types. Increased Normalized Difference Vegetation Index (NDVI) was associated with a lower stroke incidence in both cohort types, whereas an increase in impervious surface was associated with an increase in stroke incidence. The first PC of the air pollution domain (PM2.5, NO2 and BC) was associated with an increase in stroke incidence. For the built environment, higher levels of NDVI and lower levels of impervious surfaces were associated with a protective effect [%change in HR per 1 unit = -2.0 (95 %CI, -5.9;2.0) and -1.1(95 %CI, -2.0; -0.3) for traditional adult and administrative cohorts, respectively]. No clear patterns were observed for distance to blue spaces or temperature parameters. Conclusions: We observed increased HRs for stroke with exposure to PM2.5, NO2 and BC, lower levels of greenness and higher impervious surface in single and combined exposure models.
dc.description.sponsorship Project funded by the European Union’s Horizon 2020 research and innovation programme (No 874627). Jeroen de Bont is funded by the Svenska Forskningsrådet Formas (2022-00468) and Ulla Hamberg Angeby and Lennart Angeby Foundation 2022 (2022-02870).
dc.format.mimetype application/pdf
dc.identifier.citation de Bont J, Pickford R, Åström C, Colomar F, Dimakopoulou K, de Hoogh K, Ibi D, Katsouyanni K, Melén E, Nobile F, Pershagen G, Persson Å, Samoli E, Stafoggia M, Tonne C, Vlaanderen J, Wolf K, Vermeulen R, Peters A, Ljungman P. Mixtures of long-term exposure to ambient air pollution, built environment and temperature and stroke incidence across Europe. Environ Int. 2023 Sep;179:108136. DOI: 10.1016/j.envint.2023.108136
dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2023.108136
dc.identifier.issn 0160-4120
dc.identifier.uri http://hdl.handle.net/10230/58219
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environ Int. 2023 Sep;179:108136
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874627
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Air pollution
dc.subject.keyword Green space
dc.subject.keyword Meta-analysis
dc.subject.keyword Multiple environmental exposures
dc.subject.keyword Stroke
dc.subject.keyword Urban exposome
dc.title Mixtures of long-term exposure to ambient air pollution, built environment and temperature and stroke incidence across Europe
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)